Potential fluoride toxicity from oral medicaments: A review

The beneficial effects of fluoride on human oral health are well studied. There are numerous studies demonstrating that a small amount of fluoride delivered to the oral cavity decreases the prevalence of dental decay and results in stronger teeth and bones. However, ingestion of fluoride more than t...

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Main Authors: Rizwan Ullah, Muhammad Sohail Zafar, Nazish Shahani
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2017-08-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Online Access:http://ijbms.mums.ac.ir/article_9104_41778d9ccb9fe6fdc55b5379a8f35463.pdf
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author Rizwan Ullah
Muhammad Sohail Zafar
Nazish Shahani
author_facet Rizwan Ullah
Muhammad Sohail Zafar
Nazish Shahani
author_sort Rizwan Ullah
collection DOAJ
description The beneficial effects of fluoride on human oral health are well studied. There are numerous studies demonstrating that a small amount of fluoride delivered to the oral cavity decreases the prevalence of dental decay and results in stronger teeth and bones. However, ingestion of fluoride more than the recommended limit leads to toxicity and adverse effects. In order to update our understanding of fluoride and its potential toxicity, we have described the mechanisms of fluoride metabolism, toxic effects, and management of fluoride toxicity. The main aim of this review is to highlight the potential adverse effects of fluoride overdose and poorly understood toxicity. In addition, the related clinical significance of fluoride overdose and toxicity has been discussed.
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spelling doaj.art-5ceb90491f9749f3b349e0cbc4fe23fe2022-12-22T03:26:41ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742017-08-0120884184810.22038/ijbms.2017.91049104Potential fluoride toxicity from oral medicaments: A reviewRizwan Ullah0Muhammad Sohail Zafar1Nazish Shahani2Department of Oral Biology, Sindh Institute of Oral Health Sciences Jinnah Sindh Medical University, Karachi, PakistanDepartment of Restorative Dentistry, College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Saudi Arabia|Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad, PakistanDepartment of Oral Biology, Sindh Institute of Oral Health Sciences Jinnah Sindh Medical University, Karachi, PakistanThe beneficial effects of fluoride on human oral health are well studied. There are numerous studies demonstrating that a small amount of fluoride delivered to the oral cavity decreases the prevalence of dental decay and results in stronger teeth and bones. However, ingestion of fluoride more than the recommended limit leads to toxicity and adverse effects. In order to update our understanding of fluoride and its potential toxicity, we have described the mechanisms of fluoride metabolism, toxic effects, and management of fluoride toxicity. The main aim of this review is to highlight the potential adverse effects of fluoride overdose and poorly understood toxicity. In addition, the related clinical significance of fluoride overdose and toxicity has been discussed.http://ijbms.mums.ac.ir/article_9104_41778d9ccb9fe6fdc55b5379a8f35463.pdfFluoridationFluorideOral healthToxicityWater fluoridation
spellingShingle Rizwan Ullah
Muhammad Sohail Zafar
Nazish Shahani
Potential fluoride toxicity from oral medicaments: A review
Iranian Journal of Basic Medical Sciences
Fluoridation
Fluoride
Oral health
Toxicity
Water fluoridation
title Potential fluoride toxicity from oral medicaments: A review
title_full Potential fluoride toxicity from oral medicaments: A review
title_fullStr Potential fluoride toxicity from oral medicaments: A review
title_full_unstemmed Potential fluoride toxicity from oral medicaments: A review
title_short Potential fluoride toxicity from oral medicaments: A review
title_sort potential fluoride toxicity from oral medicaments a review
topic Fluoridation
Fluoride
Oral health
Toxicity
Water fluoridation
url http://ijbms.mums.ac.ir/article_9104_41778d9ccb9fe6fdc55b5379a8f35463.pdf
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