Towards Understanding the Pathogenicity of DROSHA Mutations in Oncohematology

Towards Understanding the Pathogenicity of DROSHA Mutations in Oncohematology

Myelodysplastic syndrome (MDS) refers to a heterogeneous group of closely related clonal hematopoietic disorders, which are characterized by accumulation of somatic mutations. The acquired mutation burden is suggested to define the pathway and consequent phenotype of the pathology. Recent studies ha...

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Bibliographic Details
Main Authors: Dmitrii S. Bug, Artem V. Tishkov, Ivan S. Moiseev, Yuri B. Porozov, Natalia V. Petukhova
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
DROSHA
myelodysplastic syndrome
variants effect prediction
protein modeling
molecular dynamics
Online Access:https://www.mdpi.com/2073-4409/10/9/2357

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