Localised Morphea Treated Empirically with Ceftriaxone
Localised morphea is an autoimmune sclerosing disorder of unknown aetiology. Various triggering factors are known to be associated with the disease including infections, vaccination, autoimmune disorders, and trauma. Amongst the infections, the common causative organisms associated with morphea are...
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JCDR Research and Publications Private Limited
2023-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/17549/60892_CE[Ra1]_F[SK]_PF1(PS_KM_OM)_PN(OM).pdf |
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| author | Deena Patil Madivalara Yallappa Suparna Shruthi Madhavi Govindarajulu Tharayil Kunneth Sumathy |
| author_facet | Deena Patil Madivalara Yallappa Suparna Shruthi Madhavi Govindarajulu Tharayil Kunneth Sumathy |
| author_sort | Deena Patil |
| collection | DOAJ |
| description | Localised morphea is an autoimmune sclerosing disorder of unknown aetiology. Various triggering factors are known to be associated with the disease including infections, vaccination, autoimmune disorders, and trauma. Amongst the infections, the common causative organisms associated with morphea are Borrelia burgdorferi, varicella, and Epstein-Barr virus (EBV). Localised morphea presents as an initial inflammatory stage and a late inactive stage. It is characterised by sclerosis of skin with hyper or depigmentation. The antibiotics effective against borrelia infection are benzyl penicillin, doxycycline, and ceftriaxone. These antibiotics are tried in the treatment of localised morphea. Ceftriaxone is one of the best antibiotics preferred to treat borrelia infection at all stages. Apart from its antibiotic properties, it also has an anti-inflammatory and collagen remodelling properties. All five cases of localised morphea reported here were biopsy proven, Antinuclear Antibody (ANA) and Rheumatoid Arthritis (RA) factor negative. All the cases were treated with weekly single intramuscular dose of ceftriaxone 250 mg. After eight weeks there was remarkable improvement in the induration and pigmentation of the lesions. |
| first_indexed | 2024-04-10T00:24:12Z |
| format | Article |
| id | doaj.art-5cf01059c4e945149d7cd2a0f0350007 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T00:24:12Z |
| publishDate | 2023-02-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-5cf01059c4e945149d7cd2a0f03500072023-03-15T11:53:13ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-02-01172WR01WR0310.7860/JCDR/2023/60892.17549Localised Morphea Treated Empirically with CeftriaxoneDeena Patil0Madivalara Yallappa Suparna1Shruthi Madhavi Govindarajulu2Tharayil Kunneth Sumathy3Assistant Professor, Department of Dermatology, MS Ramaiah Medical College, Bengaluru, Karnataka, India.Assistant Professor, Department of Dermatology, MS Ramaiah Medical College, Bengaluru, Karnataka, India.Senior Resident, Department of Dermatology, MS Ramaiah Medical College, Bengaluru, Karnataka, India.Professor and Head, Department of Dermatology, MS Ramaiah Medical College, Bengaluru, Karnataka, India.Localised morphea is an autoimmune sclerosing disorder of unknown aetiology. Various triggering factors are known to be associated with the disease including infections, vaccination, autoimmune disorders, and trauma. Amongst the infections, the common causative organisms associated with morphea are Borrelia burgdorferi, varicella, and Epstein-Barr virus (EBV). Localised morphea presents as an initial inflammatory stage and a late inactive stage. It is characterised by sclerosis of skin with hyper or depigmentation. The antibiotics effective against borrelia infection are benzyl penicillin, doxycycline, and ceftriaxone. These antibiotics are tried in the treatment of localised morphea. Ceftriaxone is one of the best antibiotics preferred to treat borrelia infection at all stages. Apart from its antibiotic properties, it also has an anti-inflammatory and collagen remodelling properties. All five cases of localised morphea reported here were biopsy proven, Antinuclear Antibody (ANA) and Rheumatoid Arthritis (RA) factor negative. All the cases were treated with weekly single intramuscular dose of ceftriaxone 250 mg. After eight weeks there was remarkable improvement in the induration and pigmentation of the lesions.https://jcdr.net/articles/PDF/17549/60892_CE[Ra1]_F[SK]_PF1(PS_KM_OM)_PN(OM).pdfantibioticsinfectionscleroderma |
| spellingShingle | Deena Patil Madivalara Yallappa Suparna Shruthi Madhavi Govindarajulu Tharayil Kunneth Sumathy Localised Morphea Treated Empirically with Ceftriaxone Journal of Clinical and Diagnostic Research antibiotics infection scleroderma |
| title | Localised Morphea Treated Empirically with Ceftriaxone |
| title_full | Localised Morphea Treated Empirically with Ceftriaxone |
| title_fullStr | Localised Morphea Treated Empirically with Ceftriaxone |
| title_full_unstemmed | Localised Morphea Treated Empirically with Ceftriaxone |
| title_short | Localised Morphea Treated Empirically with Ceftriaxone |
| title_sort | localised morphea treated empirically with ceftriaxone |
| topic | antibiotics infection scleroderma |
| url | https://jcdr.net/articles/PDF/17549/60892_CE[Ra1]_F[SK]_PF1(PS_KM_OM)_PN(OM).pdf |
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