A Review on the Carcinogenic Roles of DSCAM-AS1
Long non-coding RNAs (lncRNAs) are a group of transcripts with fundamental roles in the carcinogenesis. DSCAM Antisense RNA 1 (DSCAM−AS1) is an example of this group of transcripts which has been firstly identified in an attempt to find differentially expressed transcripts between breast tumor cells...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.758513/full |
| _version_ | 1818726147213492224 |
|---|---|
| author | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Mohammad Taheri Kaveh Ebrahimzadeh |
| author_facet | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Mohammad Taheri Kaveh Ebrahimzadeh |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are a group of transcripts with fundamental roles in the carcinogenesis. DSCAM Antisense RNA 1 (DSCAM−AS1) is an example of this group of transcripts which has been firstly identified in an attempt to find differentially expressed transcripts between breast tumor cells and benign breast samples. The pathogenic roles of DSCAM-AS1 have been vastly assessed in breast cancer, yet its roles are not restricted to this type of cancer. Independent studies in non-small cell lung cancer, colorectal cancer, osteosarcoma, hepatocellular carcinoma, melanoma and cervical cancer have validated participation of DSCAM-AS1 in the carcinogenic processes. miR-577, miR-122-5p, miR-204-5p, miR-136, miR−137, miR−382, miR−183, miR−99, miR-3173-5p, miR-874-3p, miR-874-3p, miR-150-5p, miR-2467-3p, miR-216b, miR-384, miR-186-5p, miR-338-3p, miR-877-5p and miR-101 are among miRNAs which interact with DSCAM-AS1. Moreover, this lncRNA has interactions with Wnt/β-catenin pathway. The current study aims at summarization of the results of studies which focused on the assessment of oncogenic role of DSCAM-AS1. |
| first_indexed | 2024-12-17T21:53:35Z |
| format | Article |
| id | doaj.art-5cf27ab8349743f8a78480ca6d170463 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T21:53:35Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-5cf27ab8349743f8a78480ca6d1704632022-12-21T21:31:11ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-10-01910.3389/fcell.2021.758513758513A Review on the Carcinogenic Roles of DSCAM-AS1Soudeh Ghafouri-Fard0Tayyebeh Khoshbakht1Mohammad Taheri2Kaveh Ebrahimzadeh3Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranMen’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranLong non-coding RNAs (lncRNAs) are a group of transcripts with fundamental roles in the carcinogenesis. DSCAM Antisense RNA 1 (DSCAM−AS1) is an example of this group of transcripts which has been firstly identified in an attempt to find differentially expressed transcripts between breast tumor cells and benign breast samples. The pathogenic roles of DSCAM-AS1 have been vastly assessed in breast cancer, yet its roles are not restricted to this type of cancer. Independent studies in non-small cell lung cancer, colorectal cancer, osteosarcoma, hepatocellular carcinoma, melanoma and cervical cancer have validated participation of DSCAM-AS1 in the carcinogenic processes. miR-577, miR-122-5p, miR-204-5p, miR-136, miR−137, miR−382, miR−183, miR−99, miR-3173-5p, miR-874-3p, miR-874-3p, miR-150-5p, miR-2467-3p, miR-216b, miR-384, miR-186-5p, miR-338-3p, miR-877-5p and miR-101 are among miRNAs which interact with DSCAM-AS1. Moreover, this lncRNA has interactions with Wnt/β-catenin pathway. The current study aims at summarization of the results of studies which focused on the assessment of oncogenic role of DSCAM-AS1.https://www.frontiersin.org/articles/10.3389/fcell.2021.758513/fullDSCAM-AS1M41lncRNAcancerbiomarker |
| spellingShingle | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Mohammad Taheri Kaveh Ebrahimzadeh A Review on the Carcinogenic Roles of DSCAM-AS1 Frontiers in Cell and Developmental Biology DSCAM-AS1 M41 lncRNA cancer biomarker |
| title | A Review on the Carcinogenic Roles of DSCAM-AS1 |
| title_full | A Review on the Carcinogenic Roles of DSCAM-AS1 |
| title_fullStr | A Review on the Carcinogenic Roles of DSCAM-AS1 |
| title_full_unstemmed | A Review on the Carcinogenic Roles of DSCAM-AS1 |
| title_short | A Review on the Carcinogenic Roles of DSCAM-AS1 |
| title_sort | review on the carcinogenic roles of dscam as1 |
| topic | DSCAM-AS1 M41 lncRNA cancer biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.758513/full |
| work_keys_str_mv | AT soudehghafourifard areviewonthecarcinogenicrolesofdscamas1 AT tayyebehkhoshbakht areviewonthecarcinogenicrolesofdscamas1 AT mohammadtaheri areviewonthecarcinogenicrolesofdscamas1 AT kavehebrahimzadeh areviewonthecarcinogenicrolesofdscamas1 AT soudehghafourifard reviewonthecarcinogenicrolesofdscamas1 AT tayyebehkhoshbakht reviewonthecarcinogenicrolesofdscamas1 AT mohammadtaheri reviewonthecarcinogenicrolesofdscamas1 AT kavehebrahimzadeh reviewonthecarcinogenicrolesofdscamas1 |