Relationship between Duffy Genotype/Phenotype and Prevalence of <i>Plasmodium vivax</i> Infection: A Systematic Review
The Duffy protein, a transmembrane molecule, functions as a receptor for various chemokines and facilitates attachment between the reticulocyte and the <i>Plasmodium</i> Duffy antigen-binding protein. Duffy expression correlates with the Duffy receptor gene for the chemokine, located on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/10/463 |
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| author | Yelson Alejandro Picón-Jaimes Ivan David Lozada-Martinez Javier Esteban Orozco-Chinome Jessica Molina-Franky Domenica Acevedo-Lopez Nicole Acevedo-Lopez Maria Paz Bolaño-Romero Fabriccio J. Visconti-Lopez D. Katterine Bonilla-Aldana Alfonso J. Rodriguez-Morales |
| author_facet | Yelson Alejandro Picón-Jaimes Ivan David Lozada-Martinez Javier Esteban Orozco-Chinome Jessica Molina-Franky Domenica Acevedo-Lopez Nicole Acevedo-Lopez Maria Paz Bolaño-Romero Fabriccio J. Visconti-Lopez D. Katterine Bonilla-Aldana Alfonso J. Rodriguez-Morales |
| author_sort | Yelson Alejandro Picón-Jaimes |
| collection | DOAJ |
| description | The Duffy protein, a transmembrane molecule, functions as a receptor for various chemokines and facilitates attachment between the reticulocyte and the <i>Plasmodium</i> Duffy antigen-binding protein. Duffy expression correlates with the Duffy receptor gene for the chemokine, located on chromosome 1, and exhibits geographical variability worldwide. Traditionally, researchers have described the Duffy negative genotype as a protective factor against <i>Plasmodium vivax</i> infection. However, recent studies suggest that this microorganism’s evolution could potentially diminish this protective effect. Nevertheless, there is currently insufficient global data to demonstrate this phenomenon. This study aimed to evaluate the relationship between the Duffy genotype/phenotype and the prevalence of <i>P. vivax</i> infection. The protocol for the systematic review was registered in PROSPERO as CRD42022353427 and involved reviewing published studies from 2012 to 2022. The Medline/PubMed, Web of Science, Scopus, and SciELO databases were consulted. Assessments of study quality were conducted using the STROBE and GRADE tools. A total of 34 studies were included, with Africa accounting for the majority of recorded studies. The results varied significantly regarding the relationship between the Duffy genotype/phenotype and <i>P. vivax</i> invasion. Some studies predominantly featured the negative Duffy genotype yet reported no malaria cases. Other studies identified minor percentages of infections. Conversely, certain studies observed a higher prevalence (99%) of Duffy-negative individuals infected with <i>P. vivax.</i> In conclusion, this systematic review found that the homozygous Duffy genotype positive for the A allele (FY*A/*A) is associated with a higher incidence of <i>P. vivax</i> infection. Furthermore, the negative Duffy genotype does not confer protection against vivax malaria. |
| first_indexed | 2024-03-10T20:50:33Z |
| format | Article |
| id | doaj.art-5cf36088c5194f5987b97cc489523a9f |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T20:50:33Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-5cf36088c5194f5987b97cc489523a9f2023-11-19T18:22:59ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-09-0181046310.3390/tropicalmed8100463Relationship between Duffy Genotype/Phenotype and Prevalence of <i>Plasmodium vivax</i> Infection: A Systematic ReviewYelson Alejandro Picón-Jaimes0Ivan David Lozada-Martinez1Javier Esteban Orozco-Chinome2Jessica Molina-Franky3Domenica Acevedo-Lopez4Nicole Acevedo-Lopez5Maria Paz Bolaño-Romero6Fabriccio J. Visconti-Lopez7D. Katterine Bonilla-Aldana8Alfonso J. Rodriguez-Morales9Fac Ciències Salut Blanquerna, University Ramon Llul, 08022 Barcelona, SpainEpidemiology Program, Department of Graduate Studies in Health Sciences, Universidad Autónoma de Bucaramanga, Bucaramanga 44005, ColombiaMedical and Surgical Research Center, Future Surgeons Chapter, Colombian Surgery Association, Bogotá 10002, ColombiaDepartment of Inmunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91007, USASchool of Medicine, Fundación Universitaria Autónoma de las Américas-Institución Universitaria Visión de las Américas, Pereira 660003, ColombiaMedical and Surgical Research Center, Future Surgeons Chapter, Colombian Surgery Association, Bogotá 10002, ColombiaMedical and Surgical Research Center, Future Surgeons Chapter, Colombian Surgery Association, Bogotá 10002, ColombiaSociedad Científica de Estudiantes de Medicina—UPC, Lima 13008, PeruResearch Unit, Universidad Continental, Huancayo 12000, PeruClinical Epidemiology and Biostatistics Master Program, Universidad Cientifica del Sur, Lima 15067, PeruThe Duffy protein, a transmembrane molecule, functions as a receptor for various chemokines and facilitates attachment between the reticulocyte and the <i>Plasmodium</i> Duffy antigen-binding protein. Duffy expression correlates with the Duffy receptor gene for the chemokine, located on chromosome 1, and exhibits geographical variability worldwide. Traditionally, researchers have described the Duffy negative genotype as a protective factor against <i>Plasmodium vivax</i> infection. However, recent studies suggest that this microorganism’s evolution could potentially diminish this protective effect. Nevertheless, there is currently insufficient global data to demonstrate this phenomenon. This study aimed to evaluate the relationship between the Duffy genotype/phenotype and the prevalence of <i>P. vivax</i> infection. The protocol for the systematic review was registered in PROSPERO as CRD42022353427 and involved reviewing published studies from 2012 to 2022. The Medline/PubMed, Web of Science, Scopus, and SciELO databases were consulted. Assessments of study quality were conducted using the STROBE and GRADE tools. A total of 34 studies were included, with Africa accounting for the majority of recorded studies. The results varied significantly regarding the relationship between the Duffy genotype/phenotype and <i>P. vivax</i> invasion. Some studies predominantly featured the negative Duffy genotype yet reported no malaria cases. Other studies identified minor percentages of infections. Conversely, certain studies observed a higher prevalence (99%) of Duffy-negative individuals infected with <i>P. vivax.</i> In conclusion, this systematic review found that the homozygous Duffy genotype positive for the A allele (FY*A/*A) is associated with a higher incidence of <i>P. vivax</i> infection. Furthermore, the negative Duffy genotype does not confer protection against vivax malaria.https://www.mdpi.com/2414-6366/8/10/463<i>Plasmodium vivax</i><i>vivax</i> malariaDuffy blood group system<i>Plasmodium</i> Duffy antigen binding proteinprevalence |
| spellingShingle | Yelson Alejandro Picón-Jaimes Ivan David Lozada-Martinez Javier Esteban Orozco-Chinome Jessica Molina-Franky Domenica Acevedo-Lopez Nicole Acevedo-Lopez Maria Paz Bolaño-Romero Fabriccio J. Visconti-Lopez D. Katterine Bonilla-Aldana Alfonso J. Rodriguez-Morales Relationship between Duffy Genotype/Phenotype and Prevalence of <i>Plasmodium vivax</i> Infection: A Systematic Review Tropical Medicine and Infectious Disease <i>Plasmodium vivax</i> <i>vivax</i> malaria Duffy blood group system <i>Plasmodium</i> Duffy antigen binding protein prevalence |
| title | Relationship between Duffy Genotype/Phenotype and Prevalence of <i>Plasmodium vivax</i> Infection: A Systematic Review |
| title_full | Relationship between Duffy Genotype/Phenotype and Prevalence of <i>Plasmodium vivax</i> Infection: A Systematic Review |
| title_fullStr | Relationship between Duffy Genotype/Phenotype and Prevalence of <i>Plasmodium vivax</i> Infection: A Systematic Review |
| title_full_unstemmed | Relationship between Duffy Genotype/Phenotype and Prevalence of <i>Plasmodium vivax</i> Infection: A Systematic Review |
| title_short | Relationship between Duffy Genotype/Phenotype and Prevalence of <i>Plasmodium vivax</i> Infection: A Systematic Review |
| title_sort | relationship between duffy genotype phenotype and prevalence of i plasmodium vivax i infection a systematic review |
| topic | <i>Plasmodium vivax</i> <i>vivax</i> malaria Duffy blood group system <i>Plasmodium</i> Duffy antigen binding protein prevalence |
| url | https://www.mdpi.com/2414-6366/8/10/463 |
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