Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, China
ObjectiveTo conduct a comparative analysis of the complications and outcomes in pregnant women with and without congenital heart disease (CHD) in Beijing, China.MethodsWe compared pregnancy-related complications and outcomes experienced by women with and without CHD throughout 19,424 deliveries in B...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.765004/full |
| _version_ | 1798016118445572096 |
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| author | Yang Liu Yanna Li Jun Zhang Wenjuan Zhao Zhaoliang Bao Xiaolong Ma Yichen Zhao Cheng Zhao Kemin Liu Qing Ye Lixiao Su Yao Yang Jing Yang Gang Li Xiangming Fan Jiangang Wang |
| author_facet | Yang Liu Yanna Li Jun Zhang Wenjuan Zhao Zhaoliang Bao Xiaolong Ma Yichen Zhao Cheng Zhao Kemin Liu Qing Ye Lixiao Su Yao Yang Jing Yang Gang Li Xiangming Fan Jiangang Wang |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | ObjectiveTo conduct a comparative analysis of the complications and outcomes in pregnant women with and without congenital heart disease (CHD) in Beijing, China.MethodsWe compared pregnancy-related complications and outcomes experienced by women with and without CHD throughout 19,424 deliveries in Beijing Anzhen Hospital between 2010 and 2019, including cardiovascular and obstetric factors, fetal events, delivery methods, and other complications over a mean 5-years post-delivery follow-up period.ResultsThere were 1,040 women with CHD (5.35% of all deliveries). Compared to women without CHD, these women had longer hospital stays (7.83 ± 4.65 vs. 4.93 ± 3.26 days) and a higher death rate (1.92 vs. 0.02%). They also had a greater risk of comorbidities, including pre-term delivery (odds ratio: 13.65 vs. 6.71), heart failure (odds ratio: 4.90 vs. 0.40), and arrhythmia (odds ratio 12.69 vs. 4.69). Pulmonary hypertension, New York Heart Association functional class III~IV, and no congenital heart disease surgery prior to pregnancy were associated with adverse events such as cesarean section, pre-term delivery, and heart failure. The fetuses of mothers with CHD were more likely to be born pre-term (odds ratio: 13.65 vs. 6.71) and have low birth weight (odds ratio: 8.56 vs. 4.36). Eleven infants (1.82%) born to mothers with CHD and four infants (0.64%) born to mothers without CHD were diagnosed with CHD.ConclusionsWomen with CHD generally increase maternal and infant risk during pregnancy and the perinatal period. Pulmonary hypertension, decrease in cardiac function, and no previous CHD surgery increase the risk in women with CHD. Greater attention should be paid to pregnant women with CHD and their fetuses, newborns. |
| first_indexed | 2024-04-11T15:44:41Z |
| format | Article |
| id | doaj.art-5cf42271fb9e426dbea89fb73cd15692 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T15:44:41Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5cf42271fb9e426dbea89fb73cd156922022-12-22T04:15:36ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-01-01810.3389/fcvm.2021.765004765004Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, ChinaYang Liu0Yanna Li1Jun Zhang2Wenjuan Zhao3Zhaoliang Bao4Xiaolong Ma5Yichen Zhao6Cheng Zhao7Kemin Liu8Qing Ye9Lixiao Su10Yao Yang11Jing Yang12Gang Li13Xiangming Fan14Jiangang Wang15Department of Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Biostatistics, NJS Associates Company, Bridgewater, NJ, United StatesDepartment of Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaObjectiveTo conduct a comparative analysis of the complications and outcomes in pregnant women with and without congenital heart disease (CHD) in Beijing, China.MethodsWe compared pregnancy-related complications and outcomes experienced by women with and without CHD throughout 19,424 deliveries in Beijing Anzhen Hospital between 2010 and 2019, including cardiovascular and obstetric factors, fetal events, delivery methods, and other complications over a mean 5-years post-delivery follow-up period.ResultsThere were 1,040 women with CHD (5.35% of all deliveries). Compared to women without CHD, these women had longer hospital stays (7.83 ± 4.65 vs. 4.93 ± 3.26 days) and a higher death rate (1.92 vs. 0.02%). They also had a greater risk of comorbidities, including pre-term delivery (odds ratio: 13.65 vs. 6.71), heart failure (odds ratio: 4.90 vs. 0.40), and arrhythmia (odds ratio 12.69 vs. 4.69). Pulmonary hypertension, New York Heart Association functional class III~IV, and no congenital heart disease surgery prior to pregnancy were associated with adverse events such as cesarean section, pre-term delivery, and heart failure. The fetuses of mothers with CHD were more likely to be born pre-term (odds ratio: 13.65 vs. 6.71) and have low birth weight (odds ratio: 8.56 vs. 4.36). Eleven infants (1.82%) born to mothers with CHD and four infants (0.64%) born to mothers without CHD were diagnosed with CHD.ConclusionsWomen with CHD generally increase maternal and infant risk during pregnancy and the perinatal period. Pulmonary hypertension, decrease in cardiac function, and no previous CHD surgery increase the risk in women with CHD. Greater attention should be paid to pregnant women with CHD and their fetuses, newborns.https://www.frontiersin.org/articles/10.3389/fcvm.2021.765004/fullcongenital heart diseasepulmonary hypertensionheart failurepregnancywoman |
| spellingShingle | Yang Liu Yanna Li Jun Zhang Wenjuan Zhao Zhaoliang Bao Xiaolong Ma Yichen Zhao Cheng Zhao Kemin Liu Qing Ye Lixiao Su Yao Yang Jing Yang Gang Li Xiangming Fan Jiangang Wang Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, China Frontiers in Cardiovascular Medicine congenital heart disease pulmonary hypertension heart failure pregnancy woman |
| title | Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, China |
| title_full | Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, China |
| title_fullStr | Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, China |
| title_full_unstemmed | Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, China |
| title_short | Pregnancy Complications and Outcomes Among Women With Congenital Heart Disease in Beijing, China |
| title_sort | pregnancy complications and outcomes among women with congenital heart disease in beijing china |
| topic | congenital heart disease pulmonary hypertension heart failure pregnancy woman |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.765004/full |
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