Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons.
The output of neocortical layer 5 pyramidal cells (L5PCs) is expressed by a train of single spikes with intermittent bursts of multiple spikes at high frequencies. The bursts are the result of nonlinear dendritic properties, including Na+, Ca2+, and NMDA spikes, that interact with the ~10,000 synaps...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-11-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1009558 |
| _version_ | 1819001830865108992 |
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| author | Eilam Goldenberg Leleo Idan Segev |
| author_facet | Eilam Goldenberg Leleo Idan Segev |
| author_sort | Eilam Goldenberg Leleo |
| collection | DOAJ |
| description | The output of neocortical layer 5 pyramidal cells (L5PCs) is expressed by a train of single spikes with intermittent bursts of multiple spikes at high frequencies. The bursts are the result of nonlinear dendritic properties, including Na+, Ca2+, and NMDA spikes, that interact with the ~10,000 synapses impinging on the neuron's dendrites. Output spike bursts are thought to implement key dendritic computations, such as coincidence detection of bottom-up inputs (arriving mostly at the basal tree) and top-down inputs (arriving mostly at the apical tree). In this study we used a detailed nonlinear model of L5PC receiving excitatory and inhibitory synaptic inputs to explore the conditions for generating bursts and for modulating their properties. We established the excitatory input conditions on the basal versus the apical tree that favor burst and show that there are two distinct types of bursts. Bursts consisting of 3 or more spikes firing at < 200 Hz, which are generated by stronger excitatory input to the basal versus the apical tree, and bursts of ~2-spikes at ~250 Hz, generated by prominent apical tuft excitation. Localized and well-timed dendritic inhibition on the apical tree differentially modulates Na+, Ca2+, and NMDA spikes and, consequently, finely controls the burst output. Finally, we explored the implications of different burst classes and respective dendritic inhibition for regulating synaptic plasticity. |
| first_indexed | 2024-12-20T22:55:27Z |
| format | Article |
| id | doaj.art-5cf733ca116b416a90bc32968eb8e221 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-20T22:55:27Z |
| publishDate | 2021-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-5cf733ca116b416a90bc32968eb8e2212022-12-21T19:24:07ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-11-011711e100955810.1371/journal.pcbi.1009558Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons.Eilam Goldenberg LeleoIdan SegevThe output of neocortical layer 5 pyramidal cells (L5PCs) is expressed by a train of single spikes with intermittent bursts of multiple spikes at high frequencies. The bursts are the result of nonlinear dendritic properties, including Na+, Ca2+, and NMDA spikes, that interact with the ~10,000 synapses impinging on the neuron's dendrites. Output spike bursts are thought to implement key dendritic computations, such as coincidence detection of bottom-up inputs (arriving mostly at the basal tree) and top-down inputs (arriving mostly at the apical tree). In this study we used a detailed nonlinear model of L5PC receiving excitatory and inhibitory synaptic inputs to explore the conditions for generating bursts and for modulating their properties. We established the excitatory input conditions on the basal versus the apical tree that favor burst and show that there are two distinct types of bursts. Bursts consisting of 3 or more spikes firing at < 200 Hz, which are generated by stronger excitatory input to the basal versus the apical tree, and bursts of ~2-spikes at ~250 Hz, generated by prominent apical tuft excitation. Localized and well-timed dendritic inhibition on the apical tree differentially modulates Na+, Ca2+, and NMDA spikes and, consequently, finely controls the burst output. Finally, we explored the implications of different burst classes and respective dendritic inhibition for regulating synaptic plasticity.https://doi.org/10.1371/journal.pcbi.1009558 |
| spellingShingle | Eilam Goldenberg Leleo Idan Segev Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons. PLoS Computational Biology |
| title | Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons. |
| title_full | Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons. |
| title_fullStr | Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons. |
| title_full_unstemmed | Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons. |
| title_short | Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons. |
| title_sort | burst control synaptic conditions for burst generation in cortical layer 5 pyramidal neurons |
| url | https://doi.org/10.1371/journal.pcbi.1009558 |
| work_keys_str_mv | AT eilamgoldenbergleleo burstcontrolsynapticconditionsforburstgenerationincorticallayer5pyramidalneurons AT idansegev burstcontrolsynapticconditionsforburstgenerationincorticallayer5pyramidalneurons |