Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study
Diabetes is expected to increase up to 700 million people worldwide with type 2 diabetes being the most frequent. The use of nutritional interventions is one of the most natural approaches for managing the disease. Minerals are of paramount importance in order to preserve and obtain good health and...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1351 |
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| author | Sonya Vasto Francesca Di Gaudio Maria Raso Leo Sabatino Rosalia Caldarella Claudio De Pasquale Luigi Di Rosa Sara Baldassano |
| author_facet | Sonya Vasto Francesca Di Gaudio Maria Raso Leo Sabatino Rosalia Caldarella Claudio De Pasquale Luigi Di Rosa Sara Baldassano |
| author_sort | Sonya Vasto |
| collection | DOAJ |
| description | Diabetes is expected to increase up to 700 million people worldwide with type 2 diabetes being the most frequent. The use of nutritional interventions is one of the most natural approaches for managing the disease. Minerals are of paramount importance in order to preserve and obtain good health and among them molybdenum is an essential component. There are no studies about the consumption of biofortified food with molybdenum on glucose homeostasis but recent studies in humans suggest that molybdenum could exert hypoglycemic effects. The present study aims to assess if consumption of lettuce biofortified with molybdenum influences glucose homeostasis and whether the effects would be due to changes in gastrointestinal hormone levels and specifically Peptide YY (PYY), Glucagon-Like Peptide 1 (GLP-1), Glucagon-Like Peptide 2 (GLP-2), and Gastric Inhibitory Polypeptide (GIP). A cohort of 24 people was supplemented with biofortified lettuce for 12 days. Blood and urine samples were obtained at baseline (T0) and after 12 days (T2) of supplementation. Blood was analyzed for glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity, PYY, GLP-1, GLP-2 and GIP. Urine samples were tested for molybdenum concentration. The results showed that consumption of lettuce biofortified with molybdenum for 12 days did not affect beta cell function but significantly reduced fasting glucose, insulin, insulin resistance and increased insulin sensitivity in healthy people. Consumption of biofortified lettuce did not show any modification in urine concentration of molybdenum among the groups. These data suggest that consumption of lettuce biofortified with molybdenum improves glucose homeostasis and PYY and GIP are involved in the action mechanism. |
| first_indexed | 2024-03-09T11:33:29Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:33:29Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5cf8162bb5554f9ba4ccc270bc56b0322023-11-30T23:46:59ZengMDPI AGNutrients2072-66432022-03-01147135110.3390/nu14071351Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm StudySonya Vasto0Francesca Di Gaudio1Maria Raso2Leo Sabatino3Rosalia Caldarella4Claudio De Pasquale5Luigi Di Rosa6Sara Baldassano7Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Promoting Health, Maternal-Infant, Excellence and Internal and Specialized Medicine (ProMISE) G. D’Alessandro, University of Palermo, 90127 Palermo, ItalyChromatography and Mass Spectrometry Section, Quality Control and Chemical Risk (CQRC), Department PROMISE, University Palermo, 90133 Palermo, ItalyDipartimento Scienze Agrarie, Alimentari e Forestali (SAAF), University of Palermo, Viale delle Scienze, Ed. 5, 90128 Palermo, ItalyDepartment of Laboratory Medicine, “P. Giaccone” University Hospital, 90128 Palermo, ItalyDipartimento Scienze Agrarie, Alimentari e Forestali (SAAF), University of Palermo, Viale delle Scienze, Ed. 5, 90128 Palermo, ItalyDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDiabetes is expected to increase up to 700 million people worldwide with type 2 diabetes being the most frequent. The use of nutritional interventions is one of the most natural approaches for managing the disease. Minerals are of paramount importance in order to preserve and obtain good health and among them molybdenum is an essential component. There are no studies about the consumption of biofortified food with molybdenum on glucose homeostasis but recent studies in humans suggest that molybdenum could exert hypoglycemic effects. The present study aims to assess if consumption of lettuce biofortified with molybdenum influences glucose homeostasis and whether the effects would be due to changes in gastrointestinal hormone levels and specifically Peptide YY (PYY), Glucagon-Like Peptide 1 (GLP-1), Glucagon-Like Peptide 2 (GLP-2), and Gastric Inhibitory Polypeptide (GIP). A cohort of 24 people was supplemented with biofortified lettuce for 12 days. Blood and urine samples were obtained at baseline (T0) and after 12 days (T2) of supplementation. Blood was analyzed for glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity, PYY, GLP-1, GLP-2 and GIP. Urine samples were tested for molybdenum concentration. The results showed that consumption of lettuce biofortified with molybdenum for 12 days did not affect beta cell function but significantly reduced fasting glucose, insulin, insulin resistance and increased insulin sensitivity in healthy people. Consumption of biofortified lettuce did not show any modification in urine concentration of molybdenum among the groups. These data suggest that consumption of lettuce biofortified with molybdenum improves glucose homeostasis and PYY and GIP are involved in the action mechanism.https://www.mdpi.com/2072-6643/14/7/1351biofortificationlettucehuman heathmineralsgut peptidesGIP |
| spellingShingle | Sonya Vasto Francesca Di Gaudio Maria Raso Leo Sabatino Rosalia Caldarella Claudio De Pasquale Luigi Di Rosa Sara Baldassano Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study Nutrients biofortification lettuce human heath minerals gut peptides GIP |
| title | Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study |
| title_full | Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study |
| title_fullStr | Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study |
| title_full_unstemmed | Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study |
| title_short | Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study |
| title_sort | impact on glucose homeostasis is food biofortified with molybdenum a workable solution a two arm study |
| topic | biofortification lettuce human heath minerals gut peptides GIP |
| url | https://www.mdpi.com/2072-6643/14/7/1351 |
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