Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease amyloid precursor protein. ADAM10 is als...

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Bibliographic Details
Main Authors: Peer-Hendrik Kuhn, Alessio Vittorio Colombo, Benjamin Schusser, Daniela Dreymueller, Sebastian Wetzel, Ute Schepers, Julia Herber, Andreas Ludwig, Elisabeth Kremmer, Dirk Montag, Ulrike Müller, Michaela Schweizer, Paul Saftig, Stefan Bräse, Stefan F Lichtenthaler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
alzheimer
metalloproteases
ADAM
mass spectrometry
bioorthogonal chemistry
Online Access:https://elifesciences.org/articles/12748

Internet

https://elifesciences.org/articles/12748

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