Assessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, Australia
Abstract Background In 2017, the New South Wales Cancer Registry (NSWCR) participated in a project, supported by Cancer Australia, aiming to provide national stage data for melanoma, prostate, colorectal, breast, and lung cancers diagnosed in 2011. Simplified business rules based on the American Joi...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-6062-x |
| _version_ | 1818515845426446336 |
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| author | Sheena Lawrance Chau Bui Vidur Mahindra Maria Arcorace Claire Cooke-Yarborough |
| author_facet | Sheena Lawrance Chau Bui Vidur Mahindra Maria Arcorace Claire Cooke-Yarborough |
| author_sort | Sheena Lawrance |
| collection | DOAJ |
| description | Abstract Background In 2017, the New South Wales Cancer Registry (NSWCR) participated in a project, supported by Cancer Australia, aiming to provide national stage data for melanoma, prostate, colorectal, breast, and lung cancers diagnosed in 2011. Simplified business rules based on the American Joint Committee for Cancer (AJCC) Tumour-Node-Metastasis (TNM) stage were applied to obtain Registry-Derived (RD) stage, defined as the best estimate of TNM stage at diagnosis using routine notifications available within cancer registries. RD-stage was compared with Degree of Spread (DoS), which has been recorded for all applicable cancers in NSWCR at a population-based level since 1972, and a summary AJCC-TNM stage group, which has been collected variably since 2006. For each of the five high incidence cancers, we compared the level of improvements RD-staging provided in terms of completeness and accuracy (alignment to more clinically relevant AJCC-TNM) over DoS. Methods For each of the five cancers, stage data were extracted from NSWCR pre- and post- RD-staging to compare data completeness across all three staging systems. The alignment between DoS/RD-stage and AJCC-TNM was compared, as were the expected and observed cross-tabulated frequency distributions using a subset of NSWCR data. To determine differences between use of DoS, RD-stage, and AJCC-TNM in an epidemiological analysis, we compared survival models developed from each of the three stage variables. Results We found RD-staging provided greatest stage data completeness and alignment to AJCC-TNM for prostate cancers, followed by breast, then melanoma and lung cancers. For colorectal cancer, summary stage from DoS was confirmed as an equivalent surrogate staging system to both AJCC-TNM and RD-stage. Conclusions This analysis provides an evidence-based approach that can be used to inform decision-making for resource planning and potential implementation of a new stage data field in population-based cancer registries. |
| first_indexed | 2024-12-11T00:34:10Z |
| format | Article |
| id | doaj.art-5cf9710e935944eaabb47ad43a633f1b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T00:34:10Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-5cf9710e935944eaabb47ad43a633f1b2022-12-22T01:27:13ZengBMCBMC Cancer1471-24072019-08-0119111110.1186/s12885-019-6062-xAssessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, AustraliaSheena Lawrance0Chau Bui1Vidur Mahindra2Maria Arcorace3Claire Cooke-Yarborough4Cancer Institute NSWCancer Institute NSWCancer Institute NSWCancer Institute NSWCancer Institute NSWAbstract Background In 2017, the New South Wales Cancer Registry (NSWCR) participated in a project, supported by Cancer Australia, aiming to provide national stage data for melanoma, prostate, colorectal, breast, and lung cancers diagnosed in 2011. Simplified business rules based on the American Joint Committee for Cancer (AJCC) Tumour-Node-Metastasis (TNM) stage were applied to obtain Registry-Derived (RD) stage, defined as the best estimate of TNM stage at diagnosis using routine notifications available within cancer registries. RD-stage was compared with Degree of Spread (DoS), which has been recorded for all applicable cancers in NSWCR at a population-based level since 1972, and a summary AJCC-TNM stage group, which has been collected variably since 2006. For each of the five high incidence cancers, we compared the level of improvements RD-staging provided in terms of completeness and accuracy (alignment to more clinically relevant AJCC-TNM) over DoS. Methods For each of the five cancers, stage data were extracted from NSWCR pre- and post- RD-staging to compare data completeness across all three staging systems. The alignment between DoS/RD-stage and AJCC-TNM was compared, as were the expected and observed cross-tabulated frequency distributions using a subset of NSWCR data. To determine differences between use of DoS, RD-stage, and AJCC-TNM in an epidemiological analysis, we compared survival models developed from each of the three stage variables. Results We found RD-staging provided greatest stage data completeness and alignment to AJCC-TNM for prostate cancers, followed by breast, then melanoma and lung cancers. For colorectal cancer, summary stage from DoS was confirmed as an equivalent surrogate staging system to both AJCC-TNM and RD-stage. Conclusions This analysis provides an evidence-based approach that can be used to inform decision-making for resource planning and potential implementation of a new stage data field in population-based cancer registries.http://link.springer.com/article/10.1186/s12885-019-6062-xCancer RegistriesCancerOncologyEpidemiologyRegistryStage |
| spellingShingle | Sheena Lawrance Chau Bui Vidur Mahindra Maria Arcorace Claire Cooke-Yarborough Assessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, Australia BMC Cancer Cancer Registries Cancer Oncology Epidemiology Registry Stage |
| title | Assessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, Australia |
| title_full | Assessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, Australia |
| title_fullStr | Assessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, Australia |
| title_full_unstemmed | Assessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, Australia |
| title_short | Assessing a modified-AJCC TNM staging system in the New South Wales Cancer Registry, Australia |
| title_sort | assessing a modified ajcc tnm staging system in the new south wales cancer registry australia |
| topic | Cancer Registries Cancer Oncology Epidemiology Registry Stage |
| url | http://link.springer.com/article/10.1186/s12885-019-6062-x |
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