Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study
Introduction People who inject drugs (PWID) are at risk of invasive infections such as bloodstream infections, endocarditis, osteomyelitis and septic arthritis. Such infections require prolonged antibiotic therapy, but there is limited evidence about the optimal care model to deliver to this populat...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-04-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/4/e070236.full |
| _version_ | 1797852980141096960 |
|---|---|
| author | Andrew Stewardson Joseph Doyle Joseph S Doyle Peter Higgs Sue J Lee Andrew J Stewardson Sue Lee Naomi Runnegar Spiros Miyakis Joshua Davis Steven Tong Ben Rogers Natasha Holmes Eugene Athan Lucy O Attwood Mellissa Bryant Olga Vujovic Lucy Attwood Kate McCarthy Kevin O’Callaghan Marjoree Sehu Sarah Sparham |
| author_facet | Andrew Stewardson Joseph Doyle Joseph S Doyle Peter Higgs Sue J Lee Andrew J Stewardson Sue Lee Naomi Runnegar Spiros Miyakis Joshua Davis Steven Tong Ben Rogers Natasha Holmes Eugene Athan Lucy O Attwood Mellissa Bryant Olga Vujovic Lucy Attwood Kate McCarthy Kevin O’Callaghan Marjoree Sehu Sarah Sparham |
| collection | DOAJ |
| description | Introduction People who inject drugs (PWID) are at risk of invasive infections such as bloodstream infections, endocarditis, osteomyelitis and septic arthritis. Such infections require prolonged antibiotic therapy, but there is limited evidence about the optimal care model to deliver to this population. The Epidemiology and Management of invasive infections among people who Use drugs (EMU) study aims to (1) describe the current burden, clinical spectrum, management and outcomes of invasive infections in PWID; (2) determine the impact of currently available models of care on completion of planned antimicrobials for PWID admitted to hospital with invasive infections and (3) determine postdischarge outcomes of PWID admitted with invasive infections at 30 and 90 days.Methods and analysis EMU is a prospective multicentre cohort study of Australian public hospitals who provide care to PWIDs with invasive infections. All patients who have injected drugs in the previous six months and are admitted to a participating site for management of an invasive infection are eligible. EMU has two components: (1) EMU-Audit will collect information from medical records, including demographics, clinical presentation, management and outcomes; (2) EMU-Cohort will augment this with interviews at baseline, 30 and 90 days post-discharge, and data linkage examining readmission rates and mortality. The primary exposure is antimicrobial treatment modality, categorised as inpatient intravenous antimicrobials, outpatient antimicrobial therapy, early oral antibiotics or lipoglycopeptide. The primary outcome is confirmed completion of planned antimicrobials. We aim to recruit 146 participants over a 2-year period.Ethics and dissemination EMU has been approved by the Alfred Hospital Human Research Ethics Committee (Project number 78815.) EMU-Audit will collect non-identifiable data with a waiver of consent. EMU-Cohort will collect identifiable data with informed consent. Findings will be presented at scientific conferences and disseminated by peer-review publications.Trial registration number ACTRN12622001173785; Pre-results. |
| first_indexed | 2024-04-09T19:43:10Z |
| format | Article |
| id | doaj.art-5cfa248b83b54dbebe463688ad3b21f1 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-09T19:43:10Z |
| publishDate | 2023-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-5cfa248b83b54dbebe463688ad3b21f12023-04-04T00:00:06ZengBMJ Publishing GroupBMJ Open2044-60552023-04-0113410.1136/bmjopen-2022-070236Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study Andrew Stewardson0Joseph Doyle1Joseph S Doyle2Peter Higgs3Sue J Lee4Andrew J Stewardson5Sue LeeNaomi Runnegar6Spiros Miyakis7Joshua Davis8Steven Tong9Ben RogersNatasha Holmes10Eugene Athan11Lucy O Attwood12Mellissa Bryant13Olga Vujovic14Lucy AttwoodKate McCarthyKevin O’CallaghanMarjoree SehuSarah Sparham2 Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, Victoria, AustraliaDisease Elimination Program, Burnet Institute, Melbourne, Victoria, AustraliaDepartment of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, AustraliaDisease Elimination Program, Burnet Institute, Melbourne, Victoria, AustraliaMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, ThailandDepartment of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, AustraliaPrincess Alexandra Hospital, Metro South Health Service District, Woolloongabba, Queensland, AustraliaPapageorgious Hospital, Medicine, Aristotle University of Thessaloniki, Thessaloniki, TK 54267, GreeceCardiovascular Disease, UTHSC College of Medicine Chattanooga, Chattanooga, Tennessee, USAVictorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Victoria, AustraliaData Analytics Research and Evaluation Centre, The University of Melbourne, Melbourne, Victoria, AustraliaSchool of Medicine, Deakin University, Geelong, Victoria, AustraliaDepartment of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, AustraliaDepartment of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, AustraliaDepartment of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, AustraliaIntroduction People who inject drugs (PWID) are at risk of invasive infections such as bloodstream infections, endocarditis, osteomyelitis and septic arthritis. Such infections require prolonged antibiotic therapy, but there is limited evidence about the optimal care model to deliver to this population. The Epidemiology and Management of invasive infections among people who Use drugs (EMU) study aims to (1) describe the current burden, clinical spectrum, management and outcomes of invasive infections in PWID; (2) determine the impact of currently available models of care on completion of planned antimicrobials for PWID admitted to hospital with invasive infections and (3) determine postdischarge outcomes of PWID admitted with invasive infections at 30 and 90 days.Methods and analysis EMU is a prospective multicentre cohort study of Australian public hospitals who provide care to PWIDs with invasive infections. All patients who have injected drugs in the previous six months and are admitted to a participating site for management of an invasive infection are eligible. EMU has two components: (1) EMU-Audit will collect information from medical records, including demographics, clinical presentation, management and outcomes; (2) EMU-Cohort will augment this with interviews at baseline, 30 and 90 days post-discharge, and data linkage examining readmission rates and mortality. The primary exposure is antimicrobial treatment modality, categorised as inpatient intravenous antimicrobials, outpatient antimicrobial therapy, early oral antibiotics or lipoglycopeptide. The primary outcome is confirmed completion of planned antimicrobials. We aim to recruit 146 participants over a 2-year period.Ethics and dissemination EMU has been approved by the Alfred Hospital Human Research Ethics Committee (Project number 78815.) EMU-Audit will collect non-identifiable data with a waiver of consent. EMU-Cohort will collect identifiable data with informed consent. Findings will be presented at scientific conferences and disseminated by peer-review publications.Trial registration number ACTRN12622001173785; Pre-results.https://bmjopen.bmj.com/content/13/4/e070236.full |
| spellingShingle | Andrew Stewardson Joseph Doyle Joseph S Doyle Peter Higgs Sue J Lee Andrew J Stewardson Sue Lee Naomi Runnegar Spiros Miyakis Joshua Davis Steven Tong Ben Rogers Natasha Holmes Eugene Athan Lucy O Attwood Mellissa Bryant Olga Vujovic Lucy Attwood Kate McCarthy Kevin O’Callaghan Marjoree Sehu Sarah Sparham Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study BMJ Open |
| title | Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study |
| title_full | Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study |
| title_fullStr | Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study |
| title_full_unstemmed | Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study |
| title_short | Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study |
| title_sort | epidemiology and management of invasive infections among people who use drugs emu protocol for a prospective multicentre cohort study |
| url | https://bmjopen.bmj.com/content/13/4/e070236.full |
| work_keys_str_mv | AT epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT andrewstewardson epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT josephdoyle epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT josephsdoyle epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT peterhiggs epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT suejlee epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT andrewjstewardson epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT suelee epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT naomirunnegar epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT spirosmiyakis epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT joshuadavis epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT steventong epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT benrogers epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT natashaholmes epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT eugeneathan epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT lucyoattwood epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT mellissabryant epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT olgavujovic epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT lucyattwood epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT katemccarthy epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT kevinocallaghan epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT marjoreesehu epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy AT sarahsparham epidemiologyandmanagementofinvasiveinfectionsamongpeoplewhousedrugsemuprotocolforaprospectivemulticentrecohortstudy |