Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins
Background & Objective: Due to The limitation of research literature, related to the effect of exercise training with different intensity, Along with Hypoxia Stress on Pulmonary Apoptosis, The purpose of this study was to investigate the effects of hypoxia and taper on expression of Bax and Bcl2...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2018-07-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1526-en.pdf |
| _version_ | 1797679622839599104 |
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| author | Mehdi Yadegari Simin Riahy Shadmehr Mirdar Gholamreza Hamidiyan Parinaz Mosadegh Fariba Yahyavi |
| author_facet | Mehdi Yadegari Simin Riahy Shadmehr Mirdar Gholamreza Hamidiyan Parinaz Mosadegh Fariba Yahyavi |
| author_sort | Mehdi Yadegari |
| collection | DOAJ |
| description | Background & Objective: Due to The limitation of research literature, related to the effect of exercise training with different intensity, Along with Hypoxia Stress on Pulmonary Apoptosis, The purpose of this study was to investigate the effects of hypoxia and taper on expression of Bax and Bcl2 apoptotic proteins of lung.
Materials & Methods: In this experimental study Twenty-four rats (4-week old, 72±8 gr) were divided accidentally to control and training groups. The samples after 6 weeks anaerobic exercise training, were exposed to Environment hypoxia and lived three weeks over there. Another group Concurrent with exposure to hypoxic environment, implementation Taper (30% reduction in exercise intensity) technique. In lung tissue, the expression of Bax and Bcl2 was studied by the immunohistochemical methods. One-way Anova was performed to analyze data. P≤0.05 was considered statistically significant.
Results:Expression of Bcl2 protein in trained rats and exposed to hypoxic stress was increased And reduced after a 3-week use of the taper(P>0.05). Expression of Bax protein in trained rats and exposed to hypoxic stress was increased (P≤0.05), and reduced after a 3-week use of the taper (P>0.05).
Conclusion: It seems that, Medium hypoxia is able to apply Apoptotic effects in lung of rats that underwent intensive exercise and likely the use of intensity taper reduces these effects. |
| first_indexed | 2024-03-11T23:17:28Z |
| format | Article |
| id | doaj.art-5cfbb099e7754e8b8d8cb28311ccf73f |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:28Z |
| publishDate | 2018-07-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-5cfbb099e7754e8b8d8cb28311ccf73f2023-09-20T21:24:09ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232018-07-0182815824Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteinsMehdi Yadegari0Simin Riahy1Shadmehr Mirdar2Gholamreza Hamidiyan3Parinaz Mosadegh4Fariba Yahyavi5 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran Faculty of Aerospace Medicine and subsurface, Army Medical University, Tehran, Iran Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz Department of Basic Sciences, Faculty of Veterinary Medicine, University of Mashhad, Mashhad, Iran Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran Background & Objective: Due to The limitation of research literature, related to the effect of exercise training with different intensity, Along with Hypoxia Stress on Pulmonary Apoptosis, The purpose of this study was to investigate the effects of hypoxia and taper on expression of Bax and Bcl2 apoptotic proteins of lung. Materials & Methods: In this experimental study Twenty-four rats (4-week old, 72±8 gr) were divided accidentally to control and training groups. The samples after 6 weeks anaerobic exercise training, were exposed to Environment hypoxia and lived three weeks over there. Another group Concurrent with exposure to hypoxic environment, implementation Taper (30% reduction in exercise intensity) technique. In lung tissue, the expression of Bax and Bcl2 was studied by the immunohistochemical methods. One-way Anova was performed to analyze data. P≤0.05 was considered statistically significant. Results:Expression of Bcl2 protein in trained rats and exposed to hypoxic stress was increased And reduced after a 3-week use of the taper(P>0.05). Expression of Bax protein in trained rats and exposed to hypoxic stress was increased (P≤0.05), and reduced after a 3-week use of the taper (P>0.05). Conclusion: It seems that, Medium hypoxia is able to apply Apoptotic effects in lung of rats that underwent intensive exercise and likely the use of intensity taper reduces these effects.http://jabs.fums.ac.ir/article-1-1526-en.pdfapoptosisbaxbcl2hypoxiataper |
| spellingShingle | Mehdi Yadegari Simin Riahy Shadmehr Mirdar Gholamreza Hamidiyan Parinaz Mosadegh Fariba Yahyavi Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins Journal of Advanced Biomedical Sciences apoptosis bax bcl2 hypoxia taper |
| title | Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins |
| title_full | Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins |
| title_fullStr | Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins |
| title_full_unstemmed | Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins |
| title_short | Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins |
| title_sort | evaluating the effects of hypoxia and taper on expression of pulmonary bax and bcl2 apoptotic proteins |
| topic | apoptosis bax bcl2 hypoxia taper |
| url | http://jabs.fums.ac.ir/article-1-1526-en.pdf |
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