Molecular diversity of <it>Mycobacterium tuberculosis </it>isolates from patients with pulmonary tuberculosis in Mozambique
<p>Abstract</p> <p>Background</p> <p>Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genotypes of <it>Mycobacterium tuberculosis </it>circulating in the country are imp...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-07-01
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| Series: | BMC Microbiology |
| Online Access: | http://www.biomedcentral.com/1471-2180/10/195 |
| _version_ | 1811248256979566592 |
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| author | Hill Véronique Miotto Paolo Cuna Zaina Gudo Paula S Pennhag Alexandra Ghebremichael Solomon Groenheit Ramona Machado Adelina Viegas Sofia O Marrufo Tatiana Cirillo Daniela M Rastogi Nalin Källenius Gunilla Koivula Tuija |
| author_facet | Hill Véronique Miotto Paolo Cuna Zaina Gudo Paula S Pennhag Alexandra Ghebremichael Solomon Groenheit Ramona Machado Adelina Viegas Sofia O Marrufo Tatiana Cirillo Daniela M Rastogi Nalin Källenius Gunilla Koivula Tuija |
| author_sort | Hill Véronique |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genotypes of <it>Mycobacterium tuberculosis </it>circulating in the country are important to better understand the epidemic. This study determined the predominant strain lineages that cause TB in Mozambique.</p> <p>Results</p> <p>A total of 445 <it>M. tuberculosis </it>isolates from seven different provinces of Mozambique were characterized by spoligotyping and resulting profiles were compared with the international spoligotyping database SITVIT2.</p> <p>The four most predominant lineages observed were: the Latin-American Mediterranean (LAM, n = 165 or 37%); the East African-Indian (EAI, n = 132 or 29.7%); an evolutionary recent but yet ill-defined T clade, (n = 52 or 11.6%); and the globally-emerging Beijing clone, (n = 31 or 7%). A high spoligotype diversity was found for the EAI, LAM and T lineages.</p> <p>Conclusions</p> <p>The TB epidemic in Mozambique is caused by a wide diversity of spoligotypes with predominance of LAM, EAI, T and Beijing lineages.</p> |
| first_indexed | 2024-04-12T15:24:52Z |
| format | Article |
| id | doaj.art-5cfbcba6b74d4aa2b146be96246801f1 |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-04-12T15:24:52Z |
| publishDate | 2010-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-5cfbcba6b74d4aa2b146be96246801f12022-12-22T03:27:18ZengBMCBMC Microbiology1471-21802010-07-0110119510.1186/1471-2180-10-195Molecular diversity of <it>Mycobacterium tuberculosis </it>isolates from patients with pulmonary tuberculosis in MozambiqueHill VéroniqueMiotto PaoloCuna ZainaGudo Paula SPennhag AlexandraGhebremichael SolomonGroenheit RamonaMachado AdelinaViegas Sofia OMarrufo TatianaCirillo Daniela MRastogi NalinKällenius GunillaKoivula Tuija<p>Abstract</p> <p>Background</p> <p>Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genotypes of <it>Mycobacterium tuberculosis </it>circulating in the country are important to better understand the epidemic. This study determined the predominant strain lineages that cause TB in Mozambique.</p> <p>Results</p> <p>A total of 445 <it>M. tuberculosis </it>isolates from seven different provinces of Mozambique were characterized by spoligotyping and resulting profiles were compared with the international spoligotyping database SITVIT2.</p> <p>The four most predominant lineages observed were: the Latin-American Mediterranean (LAM, n = 165 or 37%); the East African-Indian (EAI, n = 132 or 29.7%); an evolutionary recent but yet ill-defined T clade, (n = 52 or 11.6%); and the globally-emerging Beijing clone, (n = 31 or 7%). A high spoligotype diversity was found for the EAI, LAM and T lineages.</p> <p>Conclusions</p> <p>The TB epidemic in Mozambique is caused by a wide diversity of spoligotypes with predominance of LAM, EAI, T and Beijing lineages.</p>http://www.biomedcentral.com/1471-2180/10/195 |
| spellingShingle | Hill Véronique Miotto Paolo Cuna Zaina Gudo Paula S Pennhag Alexandra Ghebremichael Solomon Groenheit Ramona Machado Adelina Viegas Sofia O Marrufo Tatiana Cirillo Daniela M Rastogi Nalin Källenius Gunilla Koivula Tuija Molecular diversity of <it>Mycobacterium tuberculosis </it>isolates from patients with pulmonary tuberculosis in Mozambique BMC Microbiology |
| title | Molecular diversity of <it>Mycobacterium tuberculosis </it>isolates from patients with pulmonary tuberculosis in Mozambique |
| title_full | Molecular diversity of <it>Mycobacterium tuberculosis </it>isolates from patients with pulmonary tuberculosis in Mozambique |
| title_fullStr | Molecular diversity of <it>Mycobacterium tuberculosis </it>isolates from patients with pulmonary tuberculosis in Mozambique |
| title_full_unstemmed | Molecular diversity of <it>Mycobacterium tuberculosis </it>isolates from patients with pulmonary tuberculosis in Mozambique |
| title_short | Molecular diversity of <it>Mycobacterium tuberculosis </it>isolates from patients with pulmonary tuberculosis in Mozambique |
| title_sort | molecular diversity of it mycobacterium tuberculosis it isolates from patients with pulmonary tuberculosis in mozambique |
| url | http://www.biomedcentral.com/1471-2180/10/195 |
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