Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response
Abstract After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogest...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
|
| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-023-02625-w |
| _version_ | 1797273526460219392 |
|---|---|
| author | Caroline Sevoz-Couche Maxime Patout Beny Charbit Thomas Similowski Christian Straus |
| author_facet | Caroline Sevoz-Couche Maxime Patout Beny Charbit Thomas Similowski Christian Straus |
| author_sort | Caroline Sevoz-Couche |
| collection | DOAJ |
| description | Abstract After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment. Clinical Trials Identifier NCT01243697 |
| first_indexed | 2024-03-07T14:44:38Z |
| format | Article |
| id | doaj.art-5cfdcd886e0344169964d85bd8b04395 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-03-07T14:44:38Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-5cfdcd886e0344169964d85bd8b043952024-03-05T20:02:38ZengBMCRespiratory Research1465-993X2024-02-012511610.1186/s12931-023-02625-wHigher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory responseCaroline Sevoz-Couche0Maxime Patout1Beny Charbit2Thomas Similowski3Christian Straus4Sorbonne Université, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et CliniqueSorbonne Université, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et CliniqueFaculté de Médecine, EA 3801, Université de Reims Champagne ArdenneSorbonne Université, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et CliniqueSorbonne Université, UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et CliniqueAbstract After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment. Clinical Trials Identifier NCT01243697https://doi.org/10.1186/s12931-023-02625-wHypoventilation syndromeDesogestrelAutonomic nervous systemHeart rate variability |
| spellingShingle | Caroline Sevoz-Couche Maxime Patout Beny Charbit Thomas Similowski Christian Straus Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response Respiratory Research Hypoventilation syndrome Desogestrel Autonomic nervous system Heart rate variability |
| title | Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response |
| title_full | Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response |
| title_fullStr | Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response |
| title_full_unstemmed | Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response |
| title_short | Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response |
| title_sort | higher baseline heart rate variability in cchs patients with progestin associated recovery of hypercapnic ventilatory response |
| topic | Hypoventilation syndrome Desogestrel Autonomic nervous system Heart rate variability |
| url | https://doi.org/10.1186/s12931-023-02625-w |
| work_keys_str_mv | AT carolinesevozcouche higherbaselineheartratevariabilityincchspatientswithprogestinassociatedrecoveryofhypercapnicventilatoryresponse AT maximepatout higherbaselineheartratevariabilityincchspatientswithprogestinassociatedrecoveryofhypercapnicventilatoryresponse AT benycharbit higherbaselineheartratevariabilityincchspatientswithprogestinassociatedrecoveryofhypercapnicventilatoryresponse AT thomassimilowski higherbaselineheartratevariabilityincchspatientswithprogestinassociatedrecoveryofhypercapnicventilatoryresponse AT christianstraus higherbaselineheartratevariabilityincchspatientswithprogestinassociatedrecoveryofhypercapnicventilatoryresponse |