Antibiotic exposure and asthma development in children with allergic rhinitis
Purpose: Early-life antibiotic use may be associated with asthma, yet whether this association also exists in patients with allergic rhinitis (AR) remains unknown. We investigated the association between antibiotic exposure and asthma development in AR children. Methods: AR patients less than 18 yea...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118218302159 |
| _version_ | 1819043367599734784 |
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| author | Yi-Ching Lin Yen-Chun Chen Chang-Hung Kuo Yu-Han Chang Hsin-Yi Huang Wei-Ju Yeh Ting-Yi Wu Ming-Yii Huang Chih-Hsing Hung |
| author_facet | Yi-Ching Lin Yen-Chun Chen Chang-Hung Kuo Yu-Han Chang Hsin-Yi Huang Wei-Ju Yeh Ting-Yi Wu Ming-Yii Huang Chih-Hsing Hung |
| author_sort | Yi-Ching Lin |
| collection | DOAJ |
| description | Purpose: Early-life antibiotic use may be associated with asthma, yet whether this association also exists in patients with allergic rhinitis (AR) remains unknown. We investigated the association between antibiotic exposure and asthma development in AR children. Methods: AR patients less than 18 year-old were enrolled from the Taiwan National Health Insurance Database, which reported information from 2005 to 2010. The case group was defined as having newly developed asthma, and the control group was defined as never having an asthma diagnosis. The age of first exposure to antibiotic prescriptions and antibiotic exposure records preceding 5 years before the first asthma diagnosis were obtained from drug prescription records. The odds ratio (OR) was examined after adjusting for age, gender, resident urbanization, underlying medical disorders and medications. Results: A total of 3236 AR patients with newly developed asthma and 9708 AR patients without asthma were included in this study. Antibiotic exposure before the age of 3 years was not associated with asthma development. Preceding 5-year antibiotic exposure increased the risk of asthma development with a dose-response relationship, even for antibiotics with low cumulative defined daily doses (adjusted OR 1.40, 95% CI 1.12–1.75). Preceding 5-year exposure to penicillin and macrolide significantly increased the risk of asthma when diagnosed before age 12 in AR patients, but this was not statistically significant when asthma diagnosed after age 12. Conclusion: Preceding 5-year antibiotic exposure, particularly to penicillin group of amoxicillin and macrolides, is associated with the risk of asthma development before age 12 in AR children. |
| first_indexed | 2024-12-21T09:55:40Z |
| format | Article |
| id | doaj.art-5cfe1f7725ea49cbae606e2817a66bc7 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-12-21T09:55:40Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-5cfe1f7725ea49cbae606e2817a66bc72022-12-21T19:08:04ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822020-10-01535803811Antibiotic exposure and asthma development in children with allergic rhinitisYi-Ching Lin0Yen-Chun Chen1Chang-Hung Kuo2Yu-Han Chang3Hsin-Yi Huang4Wei-Ju Yeh5Ting-Yi Wu6Ming-Yii Huang7Chih-Hsing Hung8Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TaiwanTa-Kuo Clinic, Kaohsiung, TaiwanTeaching and Research Center of Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TaiwanTeaching and Research Center of Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TaiwanTeaching and Research Center of Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TaiwanTeaching and Research Center of Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, TaiwanDepartment of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Radiation Oncology, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan; Teaching and Research Center of Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan; Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Corresponding author. Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, #100, Tz-You 1st Road, Kaohsiung, 807, Taiwan. Fax: +886 7 3213931.Purpose: Early-life antibiotic use may be associated with asthma, yet whether this association also exists in patients with allergic rhinitis (AR) remains unknown. We investigated the association between antibiotic exposure and asthma development in AR children. Methods: AR patients less than 18 year-old were enrolled from the Taiwan National Health Insurance Database, which reported information from 2005 to 2010. The case group was defined as having newly developed asthma, and the control group was defined as never having an asthma diagnosis. The age of first exposure to antibiotic prescriptions and antibiotic exposure records preceding 5 years before the first asthma diagnosis were obtained from drug prescription records. The odds ratio (OR) was examined after adjusting for age, gender, resident urbanization, underlying medical disorders and medications. Results: A total of 3236 AR patients with newly developed asthma and 9708 AR patients without asthma were included in this study. Antibiotic exposure before the age of 3 years was not associated with asthma development. Preceding 5-year antibiotic exposure increased the risk of asthma development with a dose-response relationship, even for antibiotics with low cumulative defined daily doses (adjusted OR 1.40, 95% CI 1.12–1.75). Preceding 5-year exposure to penicillin and macrolide significantly increased the risk of asthma when diagnosed before age 12 in AR patients, but this was not statistically significant when asthma diagnosed after age 12. Conclusion: Preceding 5-year antibiotic exposure, particularly to penicillin group of amoxicillin and macrolides, is associated with the risk of asthma development before age 12 in AR children.http://www.sciencedirect.com/science/article/pii/S1684118218302159AsthmaAllergic rhinitisAntibioticsChildren |
| spellingShingle | Yi-Ching Lin Yen-Chun Chen Chang-Hung Kuo Yu-Han Chang Hsin-Yi Huang Wei-Ju Yeh Ting-Yi Wu Ming-Yii Huang Chih-Hsing Hung Antibiotic exposure and asthma development in children with allergic rhinitis Journal of Microbiology, Immunology and Infection Asthma Allergic rhinitis Antibiotics Children |
| title | Antibiotic exposure and asthma development in children with allergic rhinitis |
| title_full | Antibiotic exposure and asthma development in children with allergic rhinitis |
| title_fullStr | Antibiotic exposure and asthma development in children with allergic rhinitis |
| title_full_unstemmed | Antibiotic exposure and asthma development in children with allergic rhinitis |
| title_short | Antibiotic exposure and asthma development in children with allergic rhinitis |
| title_sort | antibiotic exposure and asthma development in children with allergic rhinitis |
| topic | Asthma Allergic rhinitis Antibiotics Children |
| url | http://www.sciencedirect.com/science/article/pii/S1684118218302159 |
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