The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt
Abstract Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with varied clinical features. Disease-modifying drugs (DMDs) of MS associated with different types of thyroiditis. In this cross-sectional study, we aimed to assess the prevalence of t...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-10-01
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| Series: | The Egyptian Journal of Internal Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s43162-020-00017-w |
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| author | Nearmeen M. Rashad Marwa G. Amer Waleed M. Reda Ashour Hassan M. Hassanin |
| author_facet | Nearmeen M. Rashad Marwa G. Amer Waleed M. Reda Ashour Hassan M. Hassanin |
| author_sort | Nearmeen M. Rashad |
| collection | DOAJ |
| description | Abstract Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with varied clinical features. Disease-modifying drugs (DMDs) of MS associated with different types of thyroiditis. In this cross-sectional study, we aimed to assess the prevalence of thyroid dysfunction in MS and to investigate the association between DMDs and the risk of thyroiditis in MS. A cross-sectional study included 100 patients with relapsing-remitting multiple sclerosis (RRMS) in relapse, and the diagnosed was according to revised McDonald’s criteria 2010. Results Our results revealed that the prevalence of thyroiditis was 40%; autoimmune (34%) and infective (6%) among patients with RRMS in relapse and cerebellar symptoms were significantly higher in patients with thyroiditis compared to patients without thyroiditis. Regarding the association between DMDs and thyroiditis, the prevalence of patients treated with interferon-beta-1b was higher in MS patients with thyroiditis compared to MS patients without thyroiditis. However, the prevalence of patients treated with interferon-beta-1a was lower in MS patients with thyroiditis compared to MS patients without thyroiditis. In addition, we found CMV infection was more common in patients treated by interferon beta-1b and candida infection was common in patients treated by fingolimod. Conclusions Thyroiditis is commonly observed in patients with RRMS in relapse and higher prevalence of patients treated with interferon-beta-1b which is commonly associated with thyroiditis and CMV infection; however, candida thyroid infection was common in MS patients treated by fingolimod. |
| first_indexed | 2024-12-13T11:29:50Z |
| format | Article |
| id | doaj.art-5d00fb90ba9e46a59deeac80bad7c379 |
| institution | Directory Open Access Journal |
| issn | 1110-7782 2090-9098 |
| language | English |
| last_indexed | 2024-12-13T11:29:50Z |
| publishDate | 2020-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj.art-5d00fb90ba9e46a59deeac80bad7c3792022-12-21T23:47:58ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982020-10-013211810.1186/s43162-020-00017-wThe pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in EgyptNearmeen M. Rashad0Marwa G. Amer1Waleed M. Reda Ashour2Hassan M. Hassanin3Internal Medicine Department, Faculty of Medicine, Zagazig UniversityClinical Pathology Department, Faculty of Medicine, Zagazig UniversityNeurology Department, Faculty of Medicine, Zagazig UniversityInternal Medicine Department, Faculty of Medicine, Zagazig UniversityAbstract Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with varied clinical features. Disease-modifying drugs (DMDs) of MS associated with different types of thyroiditis. In this cross-sectional study, we aimed to assess the prevalence of thyroid dysfunction in MS and to investigate the association between DMDs and the risk of thyroiditis in MS. A cross-sectional study included 100 patients with relapsing-remitting multiple sclerosis (RRMS) in relapse, and the diagnosed was according to revised McDonald’s criteria 2010. Results Our results revealed that the prevalence of thyroiditis was 40%; autoimmune (34%) and infective (6%) among patients with RRMS in relapse and cerebellar symptoms were significantly higher in patients with thyroiditis compared to patients without thyroiditis. Regarding the association between DMDs and thyroiditis, the prevalence of patients treated with interferon-beta-1b was higher in MS patients with thyroiditis compared to MS patients without thyroiditis. However, the prevalence of patients treated with interferon-beta-1a was lower in MS patients with thyroiditis compared to MS patients without thyroiditis. In addition, we found CMV infection was more common in patients treated by interferon beta-1b and candida infection was common in patients treated by fingolimod. Conclusions Thyroiditis is commonly observed in patients with RRMS in relapse and higher prevalence of patients treated with interferon-beta-1b which is commonly associated with thyroiditis and CMV infection; however, candida thyroid infection was common in MS patients treated by fingolimod.http://link.springer.com/article/10.1186/s43162-020-00017-wRRMSThyroiditisInterferon beta-1bFingolimodDMDs |
| spellingShingle | Nearmeen M. Rashad Marwa G. Amer Waleed M. Reda Ashour Hassan M. Hassanin The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt The Egyptian Journal of Internal Medicine RRMS Thyroiditis Interferon beta-1b Fingolimod DMDs |
| title | The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt |
| title_full | The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt |
| title_fullStr | The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt |
| title_full_unstemmed | The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt |
| title_short | The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt |
| title_sort | pattern of thyroiditis in multiple sclerosis a cross sectional study in a tertiary care hospital in egypt |
| topic | RRMS Thyroiditis Interferon beta-1b Fingolimod DMDs |
| url | http://link.springer.com/article/10.1186/s43162-020-00017-w |
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