Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it has b...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/2887 |
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| author | Thu Huyen Nguyen Chau Minh Duong Xuan-Hung Nguyen Uyen Thi Trang Than |
| author_facet | Thu Huyen Nguyen Chau Minh Duong Xuan-Hung Nguyen Uyen Thi Trang Than |
| author_sort | Thu Huyen Nguyen |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it has been shown that trophic factors enveloped in extracellular vesicles (EVs), including exosomes, are a crucial aspect of MSC-based treatment for OA. Evidently, EVs derived from different MSC sources might rescue the OA phenotype by targeting many biological processes associated with cartilage extracellular matrix (ECM) degradation and exerting protective effects on different joint cell types. Despite this advancement, different studies employing EV treatment for OA have revealed reverse outcomes depending on the EV cargo, cell source, and pathological condition. Hence, in this review, we aim to summarize and discuss the possible effects of MSC-derived EVs based on recent findings at different stages of OA development, including effects on cartilage ECM, chondrocyte biology, osteocytes and bone homeostasis, inflammation, and pain management. Additionally, we discuss further strategies and technical advances for manipulating EVs to specifically target OA to bring the therapy closer to clinical use. |
| first_indexed | 2024-03-10T05:37:20Z |
| format | Article |
| id | doaj.art-5d02738539054f50b94a66f13d4f08b5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:20Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5d02738539054f50b94a66f13d4f08b52023-11-22T22:48:11ZengMDPI AGCells2073-44092021-10-011011288710.3390/cells10112887Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation ManagementThu Huyen Nguyen0Chau Minh Duong1Xuan-Hung Nguyen2Uyen Thi Trang Than3Department of Bioscience, University of Milan, 20133 Milan, ItalyVinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi 100000, VietnamVinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi 100000, VietnamVinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi 100000, VietnamOsteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells (MSCs), have been explored as a potential alternative OA therapy due to their regenerative capacity. Furthermore, it has been shown that trophic factors enveloped in extracellular vesicles (EVs), including exosomes, are a crucial aspect of MSC-based treatment for OA. Evidently, EVs derived from different MSC sources might rescue the OA phenotype by targeting many biological processes associated with cartilage extracellular matrix (ECM) degradation and exerting protective effects on different joint cell types. Despite this advancement, different studies employing EV treatment for OA have revealed reverse outcomes depending on the EV cargo, cell source, and pathological condition. Hence, in this review, we aim to summarize and discuss the possible effects of MSC-derived EVs based on recent findings at different stages of OA development, including effects on cartilage ECM, chondrocyte biology, osteocytes and bone homeostasis, inflammation, and pain management. Additionally, we discuss further strategies and technical advances for manipulating EVs to specifically target OA to bring the therapy closer to clinical use.https://www.mdpi.com/2073-4409/10/11/2887osteoarthritisextracellular vesiclesmesenchymal stem cellschondrocytesinflammationbone homeostasis |
| spellingShingle | Thu Huyen Nguyen Chau Minh Duong Xuan-Hung Nguyen Uyen Thi Trang Than Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management Cells osteoarthritis extracellular vesicles mesenchymal stem cells chondrocytes inflammation bone homeostasis |
| title | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management |
| title_full | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management |
| title_fullStr | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management |
| title_short | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management |
| title_sort | mesenchymal stem cell derived extracellular vesicles for osteoarthritis treatment extracellular matrix protection chondrocyte and osteocyte physiology pain and inflammation management |
| topic | osteoarthritis extracellular vesicles mesenchymal stem cells chondrocytes inflammation bone homeostasis |
| url | https://www.mdpi.com/2073-4409/10/11/2887 |
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