NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation

NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation

Dendritic cells (DCs) undergo rapid metabolic reprogramming to generate signal-specific immune responses. The fine control of cellular metabolism underlying DC immune tolerance remains elusive. We have recently reported that NCoR1 ablation generates immune-tolerant DCs through enhanced IL-10, IL-27...

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Bibliographic Details
Main Authors: Kaushik Sen, Rashmirekha Pati, Atimukta Jha, Gyan Prakash Mishra, Subhasish Prusty, Shweta Chaudhary, Swati Swetalika, Sreeparna Podder, Aishwarya Sen, Mamuni Swain, Ranjan Kumar Nanda, Sunil K. Raghav
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
NCoR1
Glycolysis
OXPHOS
HIF-1α
FAO
Th1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003470

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