Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study
Type 2 diabetes mellitus (T2DM) affects a vast population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in T2DM patients have not been unraveled. Research on the basic units (nodes or hubs and edges) of the brain functional network on the basis...
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| Format: | Article |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00055/full |
| _version_ | 1818595565917700096 |
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| author | Daihong Liu Shanshan Duan Chaoyang Zhou Ping Wei Lihua Chen Xuntao Yin Jiuquan Zhang Jian Wang |
| author_facet | Daihong Liu Shanshan Duan Chaoyang Zhou Ping Wei Lihua Chen Xuntao Yin Jiuquan Zhang Jian Wang |
| author_sort | Daihong Liu |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) affects a vast population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in T2DM patients have not been unraveled. Research on the basic units (nodes or hubs and edges) of the brain functional network on the basis of neuroimaging may advance our understanding of the network change pattern in T2DM patients. This study investigated the change patterns of brain functional hubs using degree centrality (DC) analysis and the connectivity among these hubs using functional connectivity and Granger causality analysis. Compared to healthy controls, the DC values were higher in the left anterior cingulate gyrus (ACG) and lower in the bilateral lateral occipital cortices (LOC) and right precentral gyrus (PreCG) in T2DM patients. The functional connectivity between the left ACG and the right PreCG was stronger in T2DM patients, whereas the functional connectivity among the right PreCG and bilateral LOC was weaker. A negative causal effect from the left ACG to left LOC and a positive effect from the left ACG to right LOC were observed in T2DM patients, while in healthy controls, the opposite occurred. Additionally, the reserve of normal brain function in T2DM patients was negatively associated with the elevated glycemic parameters. This study demonstrates that there are brain functional hubs and connectivity alterations that may reflect the aberrant information communication in the brain of T2DM patients. The findings may advance our understanding of the mechanisms of T2DM-related cognitive impairment. |
| first_indexed | 2024-12-16T11:18:03Z |
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| id | doaj.art-5d0660b868454877819d141e5d491e5e |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-16T11:18:03Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-5d0660b868454877819d141e5d491e5e2022-12-21T22:33:32ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-03-011010.3389/fnagi.2018.00055288633Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI StudyDaihong Liu0Shanshan Duan1Chaoyang Zhou2Ping Wei3Lihua Chen4Xuntao Yin5Jiuquan Zhang6Jian Wang7Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Endocrinology, The Third Affiliation Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaType 2 diabetes mellitus (T2DM) affects a vast population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in T2DM patients have not been unraveled. Research on the basic units (nodes or hubs and edges) of the brain functional network on the basis of neuroimaging may advance our understanding of the network change pattern in T2DM patients. This study investigated the change patterns of brain functional hubs using degree centrality (DC) analysis and the connectivity among these hubs using functional connectivity and Granger causality analysis. Compared to healthy controls, the DC values were higher in the left anterior cingulate gyrus (ACG) and lower in the bilateral lateral occipital cortices (LOC) and right precentral gyrus (PreCG) in T2DM patients. The functional connectivity between the left ACG and the right PreCG was stronger in T2DM patients, whereas the functional connectivity among the right PreCG and bilateral LOC was weaker. A negative causal effect from the left ACG to left LOC and a positive effect from the left ACG to right LOC were observed in T2DM patients, while in healthy controls, the opposite occurred. Additionally, the reserve of normal brain function in T2DM patients was negatively associated with the elevated glycemic parameters. This study demonstrates that there are brain functional hubs and connectivity alterations that may reflect the aberrant information communication in the brain of T2DM patients. The findings may advance our understanding of the mechanisms of T2DM-related cognitive impairment.http://journal.frontiersin.org/article/10.3389/fnagi.2018.00055/fulltype 2 diabetes mellitusresting-state functional MRIdegree centralityGranger causality analysisfunctional connectivitycognitive impairment |
| spellingShingle | Daihong Liu Shanshan Duan Chaoyang Zhou Ping Wei Lihua Chen Xuntao Yin Jiuquan Zhang Jian Wang Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study Frontiers in Aging Neuroscience type 2 diabetes mellitus resting-state functional MRI degree centrality Granger causality analysis functional connectivity cognitive impairment |
| title | Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study |
| title_full | Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study |
| title_fullStr | Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study |
| title_full_unstemmed | Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study |
| title_short | Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study |
| title_sort | altered brain functional hubs and connectivity in type 2 diabetes mellitus patients a resting state fmri study |
| topic | type 2 diabetes mellitus resting-state functional MRI degree centrality Granger causality analysis functional connectivity cognitive impairment |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00055/full |
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