Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience
Background: A vein of Galen aneurysmal malformation (VGAM) is a rare congenital cerebral vascular condition with a high mortality rate if left untreated. This study describes the long-term outcomes of patients with VGAM, who were treated with endovascular embolization. Methods: This retrospective an...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/16/2704 |
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| author | Chingiz Nurimanov Yerbol Makhambetov Karashash Menlibayeva Nurtay Nurakay Nursultan Makhambetov Elena Zholdybayeva Serik Akshulakov |
| author_facet | Chingiz Nurimanov Yerbol Makhambetov Karashash Menlibayeva Nurtay Nurakay Nursultan Makhambetov Elena Zholdybayeva Serik Akshulakov |
| author_sort | Chingiz Nurimanov |
| collection | DOAJ |
| description | Background: A vein of Galen aneurysmal malformation (VGAM) is a rare congenital cerebral vascular condition with a high mortality rate if left untreated. This study describes the long-term outcomes of patients with VGAM, who were treated with endovascular embolization. Methods: This retrospective analysis focused on VGAM patients who underwent one or more endovascular embolization sessions between January 2008 and December 2022. The study included newborns and children under 18 years. Data encompassed clinical and demographic characteristics, types of endovascular embolization, treatment complications, mortality rates, and long-term outcomes. Results: Out of 22 VGAM cases, the majority were boys (86.36%), and the average age of the participants was 38 months, ranging from 25 days to 17 years. Endovascular embolization using liquid embolizing agents was the most common intervention (50%), and around 73% of patients underwent multiple sessions. Some patients underwent ventriculoperitoneal shunting (VPS) due to persistent hydrocephalus. In long-term outcomes, four patients (18.2%) showed developmental delays, and 16 patients (72.7%) had a positive outcome. Conclusions: Combining endovascular therapy with a comprehensive management strategy significantly reduces mortality rates and improves the possibility of normal neurological development in patients. |
| first_indexed | 2024-03-11T00:00:11Z |
| format | Article |
| id | doaj.art-5d06957a05be47408b65734901371026 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T00:00:11Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-5d06957a05be47408b657349013710262023-11-19T00:48:54ZengMDPI AGDiagnostics2075-44182023-08-011316270410.3390/diagnostics13162704Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center ExperienceChingiz Nurimanov0Yerbol Makhambetov1Karashash Menlibayeva2Nurtay Nurakay3Nursultan Makhambetov4Elena Zholdybayeva5Serik Akshulakov6Vascular and Functional Neurosurgery Department, National Center for Neurosurgery, Astana 010000, KazakhstanVascular and Functional Neurosurgery Department, National Center for Neurosurgery, Astana 010000, KazakhstanHospital Management Department, National Center for Neurosurgery, Astana 010000, KazakhstanVascular and Functional Neurosurgery Department, National Center for Neurosurgery, Astana 010000, KazakhstanVascular and Functional Neurosurgery Department, National Center for Neurosurgery, Astana 010000, KazakhstanNational Scientific Shared Laboratory, National Center for Biotechnology, Astana 010000, KazakhstanVascular and Functional Neurosurgery Department, National Center for Neurosurgery, Astana 010000, KazakhstanBackground: A vein of Galen aneurysmal malformation (VGAM) is a rare congenital cerebral vascular condition with a high mortality rate if left untreated. This study describes the long-term outcomes of patients with VGAM, who were treated with endovascular embolization. Methods: This retrospective analysis focused on VGAM patients who underwent one or more endovascular embolization sessions between January 2008 and December 2022. The study included newborns and children under 18 years. Data encompassed clinical and demographic characteristics, types of endovascular embolization, treatment complications, mortality rates, and long-term outcomes. Results: Out of 22 VGAM cases, the majority were boys (86.36%), and the average age of the participants was 38 months, ranging from 25 days to 17 years. Endovascular embolization using liquid embolizing agents was the most common intervention (50%), and around 73% of patients underwent multiple sessions. Some patients underwent ventriculoperitoneal shunting (VPS) due to persistent hydrocephalus. In long-term outcomes, four patients (18.2%) showed developmental delays, and 16 patients (72.7%) had a positive outcome. Conclusions: Combining endovascular therapy with a comprehensive management strategy significantly reduces mortality rates and improves the possibility of normal neurological development in patients.https://www.mdpi.com/2075-4418/13/16/2704AV malformation of the vein of Galenthe vein of Galen aneurysmal malformationendovascular embolizationBicêtre scoreneonateshydrocephalus |
| spellingShingle | Chingiz Nurimanov Yerbol Makhambetov Karashash Menlibayeva Nurtay Nurakay Nursultan Makhambetov Elena Zholdybayeva Serik Akshulakov Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience Diagnostics AV malformation of the vein of Galen the vein of Galen aneurysmal malformation endovascular embolization Bicêtre score neonates hydrocephalus |
| title | Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience |
| title_full | Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience |
| title_fullStr | Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience |
| title_full_unstemmed | Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience |
| title_short | Long-Term Outcomes of Endovascular Embolization in a Vein of Galen Aneurysmal Malformation: A Single-Center Experience |
| title_sort | long term outcomes of endovascular embolization in a vein of galen aneurysmal malformation a single center experience |
| topic | AV malformation of the vein of Galen the vein of Galen aneurysmal malformation endovascular embolization Bicêtre score neonates hydrocephalus |
| url | https://www.mdpi.com/2075-4418/13/16/2704 |
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