Heart transplant in India: Lessons learned
Introduction: Heart Transplant in India started in 1994. We were initially doing 1-2 per year but the numbers have picked up since 2014 and we have done 25 in the past 3 years. We describe our experience of the last 4 years in this paper. Results: Initially, we experienced a relatively higher rate o...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of the Practice of Cardiovascular Sciences |
| Subjects: | |
| Online Access: | http://www.j-pcs.org/article.asp?issn=2395-5414;year=2017;volume=3;issue=2;spage=94;epage=99;aulast=Airan |
| _version_ | 1811239452803072000 |
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| author | Balram Airan Sarvesh Pal Singh Sandeep Seth Milind Padmakar Hote Manoj Kumar Sahu Palleti Rajashekar Velayoudham Devagourou Sambhunath Das Neeraj Parakh Ruma Ray Sudheer Arava |
| author_facet | Balram Airan Sarvesh Pal Singh Sandeep Seth Milind Padmakar Hote Manoj Kumar Sahu Palleti Rajashekar Velayoudham Devagourou Sambhunath Das Neeraj Parakh Ruma Ray Sudheer Arava |
| author_sort | Balram Airan |
| collection | DOAJ |
| description | Introduction: Heart Transplant in India started in 1994. We were initially doing 1-2 per year but the numbers have picked up since 2014 and we have done 25 in the past 3 years. We describe our experience of the last 4 years in this paper. Results: Initially, we experienced a relatively higher rate of rejections, fungal infections and graft failure. As we changed protocols, stopped using induction therapy except in high risk, maintained higher levels of immune suppression and tapered steroids faster in the first year, the complications reduced. All patients who had rejections and all the later transplants were maintained on a regime of tacrolimus, mycophenolate mofetil and steroids along with six months of valgancyclovir, voriconazole and co-trimoxazole. Steroids were tapered by six months to 0.1 mg/kg per day in all patients. Conclusions: In our recent patients, infection was the most common adverse event followed by rejection and PGD. In the latter half of our experience, we found that the complications reduced, suggesting that experience leads to less complications. |
| first_indexed | 2024-04-12T13:00:02Z |
| format | Article |
| id | doaj.art-5d0a943e40bc42eeb059bb791fd9d72f |
| institution | Directory Open Access Journal |
| issn | 2395-5414 2454-2830 |
| language | English |
| last_indexed | 2024-04-12T13:00:02Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Practice of Cardiovascular Sciences |
| spelling | doaj.art-5d0a943e40bc42eeb059bb791fd9d72f2022-12-22T03:32:10ZengWolters Kluwer Medknow PublicationsJournal of the Practice of Cardiovascular Sciences2395-54142454-28302017-01-0132949910.4103/jpcs.jpcs_25_17Heart transplant in India: Lessons learnedBalram AiranSarvesh Pal SinghSandeep SethMilind Padmakar HoteManoj Kumar SahuPalleti RajashekarVelayoudham DevagourouSambhunath DasNeeraj ParakhRuma RaySudheer AravaIntroduction: Heart Transplant in India started in 1994. We were initially doing 1-2 per year but the numbers have picked up since 2014 and we have done 25 in the past 3 years. We describe our experience of the last 4 years in this paper. Results: Initially, we experienced a relatively higher rate of rejections, fungal infections and graft failure. As we changed protocols, stopped using induction therapy except in high risk, maintained higher levels of immune suppression and tapered steroids faster in the first year, the complications reduced. All patients who had rejections and all the later transplants were maintained on a regime of tacrolimus, mycophenolate mofetil and steroids along with six months of valgancyclovir, voriconazole and co-trimoxazole. Steroids were tapered by six months to 0.1 mg/kg per day in all patients. Conclusions: In our recent patients, infection was the most common adverse event followed by rejection and PGD. In the latter half of our experience, we found that the complications reduced, suggesting that experience leads to less complications.http://www.j-pcs.org/article.asp?issn=2395-5414;year=2017;volume=3;issue=2;spage=94;epage=99;aulast=AiranHeartIndiatransplantAIIMS |
| spellingShingle | Balram Airan Sarvesh Pal Singh Sandeep Seth Milind Padmakar Hote Manoj Kumar Sahu Palleti Rajashekar Velayoudham Devagourou Sambhunath Das Neeraj Parakh Ruma Ray Sudheer Arava Heart transplant in India: Lessons learned Journal of the Practice of Cardiovascular Sciences Heart India transplant AIIMS |
| title | Heart transplant in India: Lessons learned |
| title_full | Heart transplant in India: Lessons learned |
| title_fullStr | Heart transplant in India: Lessons learned |
| title_full_unstemmed | Heart transplant in India: Lessons learned |
| title_short | Heart transplant in India: Lessons learned |
| title_sort | heart transplant in india lessons learned |
| topic | Heart India transplant AIIMS |
| url | http://www.j-pcs.org/article.asp?issn=2395-5414;year=2017;volume=3;issue=2;spage=94;epage=99;aulast=Airan |
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