Multiplexed Imaging Reveals the Spatial Relationship of the Extracellular Acidity-Targeting pHLIP with Necrosis, Hypoxia, and the Integrin-Targeting cRGD Peptide

Multiplexed Imaging Reveals the Spatial Relationship of the Extracellular Acidity-Targeting pHLIP with Necrosis, Hypoxia, and the Integrin-Targeting cRGD Peptide

pH (low) insertion peptides (pHLIPs) have been developed for cancer imaging and therapy targeting the acidic extracellular microenvironment. However, the characteristics of intratumoral distribution (ITD) of pHLIPs are not yet fully understood. This study aimed to reveal the details of the ITD of pH...

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Bibliographic Details
Main Authors:	Zhao-Hui Jin, Atsushi B. Tsuji, Mélissa Degardin, Pascal Dumy, Didier Boturyn, Tatsuya Higashi
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	Cells
Subjects:	pHLIP tumor acidity tumor necrosis tumor hypoxia α<sub>V</sub>β<sub>3</sub> integrin cRGD peptide
Online Access:	https://www.mdpi.com/2073-4409/11/21/3499

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