HDL Functions—Current Status and Future Perspectives
Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low HDL-C is associated with the development of CVD. However, recent epidemiology studies have shown U-shaped curves between HDL-C and CVD mortality, with paradoxically increased CVD mortality in patients with extreme...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/1/105 |
| _version_ | 1827628114928205824 |
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| author | Yasuhiro Endo Masanori Fujita Katsunori Ikewaki |
| author_facet | Yasuhiro Endo Masanori Fujita Katsunori Ikewaki |
| author_sort | Yasuhiro Endo |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low HDL-C is associated with the development of CVD. However, recent epidemiology studies have shown U-shaped curves between HDL-C and CVD mortality, with paradoxically increased CVD mortality in patients with extremely high HDL-C levels. Furthermore, HDL-C raising therapy using nicotinic acids or CETP inhibitors mostly failed to reduce CVD events. Based on this background, HDL functions rather than HDL-C could be a novel biomarker; research on the clinical utility of HDL functionality is ongoing. In this review, we summarize the current status of HDL functions and their future perspectives from the findings of basic research and clinical trials. |
| first_indexed | 2024-03-09T13:27:13Z |
| format | Article |
| id | doaj.art-5d0c24b8c69a4ca089a60930143c7ae5 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:27:13Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-5d0c24b8c69a4ca089a60930143c7ae52023-11-30T21:22:51ZengMDPI AGBiomolecules2218-273X2023-01-0113110510.3390/biom13010105HDL Functions—Current Status and Future PerspectivesYasuhiro Endo0Masanori Fujita1Katsunori Ikewaki2Division of Anti-Aging and Vascular Medicine, Department of Internal Medicine, National Defense Medical College, Saitama 359-8513, JapanDivision of Environmental Medicine, National Defense Medical College Research Institute, Saitama 359-8513, JapanDivision of Anti-Aging and Vascular Medicine, Department of Internal Medicine, National Defense Medical College, Saitama 359-8513, JapanCardiovascular disease (CVD) is the leading cause of death in Western countries. A low HDL-C is associated with the development of CVD. However, recent epidemiology studies have shown U-shaped curves between HDL-C and CVD mortality, with paradoxically increased CVD mortality in patients with extremely high HDL-C levels. Furthermore, HDL-C raising therapy using nicotinic acids or CETP inhibitors mostly failed to reduce CVD events. Based on this background, HDL functions rather than HDL-C could be a novel biomarker; research on the clinical utility of HDL functionality is ongoing. In this review, we summarize the current status of HDL functions and their future perspectives from the findings of basic research and clinical trials.https://www.mdpi.com/2218-273X/13/1/105HDLcholesterol efflux capacityreverse cholesterol transport |
| spellingShingle | Yasuhiro Endo Masanori Fujita Katsunori Ikewaki HDL Functions—Current Status and Future Perspectives Biomolecules HDL cholesterol efflux capacity reverse cholesterol transport |
| title | HDL Functions—Current Status and Future Perspectives |
| title_full | HDL Functions—Current Status and Future Perspectives |
| title_fullStr | HDL Functions—Current Status and Future Perspectives |
| title_full_unstemmed | HDL Functions—Current Status and Future Perspectives |
| title_short | HDL Functions—Current Status and Future Perspectives |
| title_sort | hdl functions current status and future perspectives |
| topic | HDL cholesterol efflux capacity reverse cholesterol transport |
| url | https://www.mdpi.com/2218-273X/13/1/105 |
| work_keys_str_mv | AT yasuhiroendo hdlfunctionscurrentstatusandfutureperspectives AT masanorifujita hdlfunctionscurrentstatusandfutureperspectives AT katsunoriikewaki hdlfunctionscurrentstatusandfutureperspectives |