Short-term fasting affects biomarkers of creatine metabolism in healthy men and women
We studied the effects of 24-h fasting on serum levels of guanidinoacetic acid (GAA), creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a sign...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Human Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149723000348 |
| _version_ | 1827620750389936128 |
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| author | Marijana Ranisavljev Nikola Todorovic Jovana Panic Bogdan Andjelic Milan Vranes Sergej M. Ostojic |
| author_facet | Marijana Ranisavljev Nikola Todorovic Jovana Panic Bogdan Andjelic Milan Vranes Sergej M. Ostojic |
| author_sort | Marijana Ranisavljev |
| collection | DOAJ |
| description | We studied the effects of 24-h fasting on serum levels of guanidinoacetic acid (GAA), creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a significant decrease in serum GAA by 39.5% (p < 0.001), while creatinine levels increased by 14.7% (p < 0.01); the concentration of creatine remains unchanged. The reduction in GAA during fasting may indicate an increased demand for creatine production for this energy-demanding condition and/or potential kidney dysfunction which requires further exploration. |
| first_indexed | 2024-03-09T10:52:22Z |
| format | Article |
| id | doaj.art-5d0c961eb9cb4de7b9524d3d9c4d2faa |
| institution | Directory Open Access Journal |
| issn | 2666-1497 |
| language | English |
| last_indexed | 2024-03-09T10:52:22Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj.art-5d0c961eb9cb4de7b9524d3d9c4d2faa2023-12-01T05:03:04ZengElsevierHuman Nutrition & Metabolism2666-14972023-12-0134200217Short-term fasting affects biomarkers of creatine metabolism in healthy men and womenMarijana Ranisavljev0Nikola Todorovic1Jovana Panic2Bogdan Andjelic3Milan Vranes4Sergej M. Ostojic5Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, SerbiaApplied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, SerbiaDepartment of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, SerbiaApplied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia; Sport and Exercise Sciences Research Unit, University of Palermo, Palermo, ItalyApplied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, SerbiaApplied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad, Serbia; Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway; Faculty of Health Sciences, University of Pécs, Pécs, Hungary; Corresponding author. pplied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, Lovcenska 16, 21000 Novi Sad, Serbia.We studied the effects of 24-h fasting on serum levels of guanidinoacetic acid (GAA), creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a significant decrease in serum GAA by 39.5% (p < 0.001), while creatinine levels increased by 14.7% (p < 0.01); the concentration of creatine remains unchanged. The reduction in GAA during fasting may indicate an increased demand for creatine production for this energy-demanding condition and/or potential kidney dysfunction which requires further exploration.http://www.sciencedirect.com/science/article/pii/S2666149723000348CreatineGuanidinoacetic acidCreatinineKidneyFasting |
| spellingShingle | Marijana Ranisavljev Nikola Todorovic Jovana Panic Bogdan Andjelic Milan Vranes Sergej M. Ostojic Short-term fasting affects biomarkers of creatine metabolism in healthy men and women Human Nutrition & Metabolism Creatine Guanidinoacetic acid Creatinine Kidney Fasting |
| title | Short-term fasting affects biomarkers of creatine metabolism in healthy men and women |
| title_full | Short-term fasting affects biomarkers of creatine metabolism in healthy men and women |
| title_fullStr | Short-term fasting affects biomarkers of creatine metabolism in healthy men and women |
| title_full_unstemmed | Short-term fasting affects biomarkers of creatine metabolism in healthy men and women |
| title_short | Short-term fasting affects biomarkers of creatine metabolism in healthy men and women |
| title_sort | short term fasting affects biomarkers of creatine metabolism in healthy men and women |
| topic | Creatine Guanidinoacetic acid Creatinine Kidney Fasting |
| url | http://www.sciencedirect.com/science/article/pii/S2666149723000348 |
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