Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial
Many individuals are suffering from depression, and various improvements are being proposed. This study was conducted on young people diagnosed with depression and aimed to assess the effects of flavonoid-rich orange juice on the major depressive disorder (MDD) using a randomized controlled trial. I...
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| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/1/145 |
| _version_ | 1797406572162318336 |
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| author | Jihee Choi Jong-Hoon Kim Miey Park Hae-Jeung Lee |
| author_facet | Jihee Choi Jong-Hoon Kim Miey Park Hae-Jeung Lee |
| author_sort | Jihee Choi |
| collection | DOAJ |
| description | Many individuals are suffering from depression, and various improvements are being proposed. This study was conducted on young people diagnosed with depression and aimed to assess the effects of flavonoid-rich orange juice on the major depressive disorder (MDD) using a randomized controlled trial. In all, 40 young men and women with MDD aged 18–29 years were randomly assigned to a flavonoid-rich orange juice group (FR group) and a flavonoid-low orange cordial group (FL group). The subjects drank the corresponding juice three times a day (190 mL per bottle) for 8 weeks. The blood BDNF, zonulin, and claudin-5 levels significantly increased (<i>p</i> < 0.0001, <i>p</i> < 0.01, and <i>p</i> < 0.05, respectively) in the FR group, and the fatty acid binding protein 2 (FABP2) level was significantly decreased (<i>p</i> < 0.0001) in the FR group after the juice intervention. The FABP2, LPS, and valeric acid levels were negatively correlated with the abundance of <i>Butyricicoccus pullicaecorum</i>, which was higher in the FR group. Orange juice intake improved depressive symptoms in young adults with MDD in the FR group. This <i>B. pullicaecorum</i> can be a potential biomarker for clinical improvement in young adults with MDD patients. |
| first_indexed | 2024-03-09T03:28:21Z |
| format | Article |
| id | doaj.art-5d0c9d2950534f2e8c75b0dae70c2d0b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:28:21Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5d0c9d2950534f2e8c75b0dae70c2d0b2023-12-03T14:59:41ZengMDPI AGNutrients2072-66432022-12-0115114510.3390/nu15010145Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled TrialJihee Choi0Jong-Hoon Kim1Miey Park2Hae-Jeung Lee3Department of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam-si 13120, Republic of KoreaDepartment of Psychiatry, Gachon University College of Medicine, Gil Medical Center, Neuroscience Research Institute, Gachon University, Incheon 21565, Republic of KoreaDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam-si 13120, Republic of KoreaDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam-si 13120, Republic of KoreaMany individuals are suffering from depression, and various improvements are being proposed. This study was conducted on young people diagnosed with depression and aimed to assess the effects of flavonoid-rich orange juice on the major depressive disorder (MDD) using a randomized controlled trial. In all, 40 young men and women with MDD aged 18–29 years were randomly assigned to a flavonoid-rich orange juice group (FR group) and a flavonoid-low orange cordial group (FL group). The subjects drank the corresponding juice three times a day (190 mL per bottle) for 8 weeks. The blood BDNF, zonulin, and claudin-5 levels significantly increased (<i>p</i> < 0.0001, <i>p</i> < 0.01, and <i>p</i> < 0.05, respectively) in the FR group, and the fatty acid binding protein 2 (FABP2) level was significantly decreased (<i>p</i> < 0.0001) in the FR group after the juice intervention. The FABP2, LPS, and valeric acid levels were negatively correlated with the abundance of <i>Butyricicoccus pullicaecorum</i>, which was higher in the FR group. Orange juice intake improved depressive symptoms in young adults with MDD in the FR group. This <i>B. pullicaecorum</i> can be a potential biomarker for clinical improvement in young adults with MDD patients.https://www.mdpi.com/2072-6643/15/1/145flavonoid therapymajor depressive disorderrandomized controlled trial<i>Butyricicoccus pullicaecorum</i> |
| spellingShingle | Jihee Choi Jong-Hoon Kim Miey Park Hae-Jeung Lee Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial Nutrients flavonoid therapy major depressive disorder randomized controlled trial <i>Butyricicoccus pullicaecorum</i> |
| title | Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial |
| title_full | Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial |
| title_fullStr | Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial |
| title_full_unstemmed | Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial |
| title_short | Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial |
| title_sort | effects of flavonoid rich orange juice intervention on major depressive disorder in young adults a randomized controlled trial |
| topic | flavonoid therapy major depressive disorder randomized controlled trial <i>Butyricicoccus pullicaecorum</i> |
| url | https://www.mdpi.com/2072-6643/15/1/145 |
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