Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway

Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway

ABSTRACT High-risk human papillomaviruses (HPVs) constitutively activate the ataxia telangiectasia and Rad3-related (ATR) DNA damage response pathway, and this is required for viral replication. In fibroblasts, activated ATR regulates transcription of inflammatory genes through its negative effects...

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Bibliographic Details
Main Authors: Shiyuan Hong, Yan Li, Paul J. Kaminski, Jorge Andrade, Laimonis A. Laimins
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
DNA replication
GATA4
HPV
inflammation
interferons
p62
Online Access:https://journals.asm.org/doi/10.1128/mBio.01628-20

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