Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma
Abstract Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 yea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1679 |
| _version_ | 1818441802502373376 |
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| author | Reiko Imai Tadashi Kamada Nobuhito Araki and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas |
| author_facet | Reiko Imai Tadashi Kamada Nobuhito Araki and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas |
| author_sort | Reiko Imai |
| collection | DOAJ |
| description | Abstract Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 years, and the median follow‐up period was 49.4 (range 6.4‐146.4) months. The median tumor volume was 356 cm3. The 5‐year local control, overall survival, and disease‐free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma. |
| first_indexed | 2024-12-14T18:34:02Z |
| format | Article |
| id | doaj.art-5d0d03e386df4b478adb4de7b5960fe9 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-14T18:34:02Z |
| publishDate | 2018-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-5d0d03e386df4b478adb4de7b5960fe92022-12-21T22:51:41ZengWileyCancer Medicine2045-76342018-09-01794308431410.1002/cam4.1679Carbon ion radiotherapy for unresectable localized axial soft tissue sarcomaReiko Imai0Tadashi Kamada1Nobuhito Araki2 and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue SarcomasHospital of the National Institute of Radiological Sciences Quantum and Radiological Science and Technology Chiba JapanHospital of the National Institute of Radiological Sciences Quantum and Radiological Science and Technology Chiba JapanDepartment of Orthopedic Surgery Ashiya Municipal Hospital Hyougo JapanAbstract Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 years, and the median follow‐up period was 49.4 (range 6.4‐146.4) months. The median tumor volume was 356 cm3. The 5‐year local control, overall survival, and disease‐free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.https://doi.org/10.1002/cam4.1679carbon ion radiotherapycharged particle therapyradiotherapysoft tissue sarcoma |
| spellingShingle | Reiko Imai Tadashi Kamada Nobuhito Araki and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma Cancer Medicine carbon ion radiotherapy charged particle therapy radiotherapy soft tissue sarcoma |
| title | Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma |
| title_full | Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma |
| title_fullStr | Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma |
| title_full_unstemmed | Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma |
| title_short | Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma |
| title_sort | carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma |
| topic | carbon ion radiotherapy charged particle therapy radiotherapy soft tissue sarcoma |
| url | https://doi.org/10.1002/cam4.1679 |
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