Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke

Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke

Nitrones are encouraging drug candidates for the treatment of oxidative stress-driven diseases such as acute ischemic stroke (AIS). In a previous study, we found a promising quinolylnitrone, QN23, which exerted a neuroprotective effect in neuronal cell cultures subjected to oxygen–glucose deprivatio...

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Bibliographic Details
Main Authors: Emma Martínez-Alonso, Alejandro Escobar-Peso, Alicia Aliena-Valero, Germán Torregrosa, Mourad Chioua, Rocío Fernández-Serra, Daniel González-Nieto, Youness Ouahid, Juan B. Salom, Jaime Masjuan, José Marco-Contelles, Alberto Alcázar
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Antioxidants
Subjects:
antioxidants
brain ischemia
ischemic stroke
neuroprotection
quinolyl nitrones
pharmacokinetics
Online Access:https://www.mdpi.com/2076-3921/11/6/1186

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