NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome
De-Gang Mo,1 Lin Wang,2 Qian-Feng Han,1 Kang Yu,3 Jia-Hui Liu,1 Heng-Chen Yao1 1Department of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, People’s Republic of China; 2Cardiologic Color Doppler Room, Liaocheng People’s Hospital Affiliated to Sha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-12-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/nlrp3-inflammasome-may-be-a-biomarker-for-risk-stratification-in-patie-peer-reviewed-fulltext-article-JIR |
| _version_ | 1811178444832112640 |
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| author | Mo DG Wang L Han QF Yu K Liu JH Yao HC |
| author_facet | Mo DG Wang L Han QF Yu K Liu JH Yao HC |
| author_sort | Mo DG |
| collection | DOAJ |
| description | De-Gang Mo,1 Lin Wang,2 Qian-Feng Han,1 Kang Yu,3 Jia-Hui Liu,1 Heng-Chen Yao1 1Department of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, People’s Republic of China; 2Cardiologic Color Doppler Room, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, People’s Republic of China; 3Department of Laboratory Medicine, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, People’s Republic of ChinaCorrespondence : Heng-Chen YaoDepartment of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, 252000, People’s Republic of China, Email yaohc66@126.comPurpose: Acute coronary syndrome (ACS) has a high incidence and mortality rate worldwide, which has a considerable negative impact on the global economy. This study aimed to identify a group of ACS patients at a high risk of recurrent adverse cardiac events using the plasma NLRP3 inflammasome.Patients and methods: ACS patients admitted to Liaocheng People’s Hospital between June 2021 and March 2022 were enrolled in this study. Patients were divided into low (levels < 3.84 ng/mL) and high (levels ≥ 3.84 ng/mL) groups based on the median NLRP3 inflammasome levels. The patients were divided into three groups according to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention (TRS-2P): low (scores ≤ 2 points), intermediate (scores = 3 points), and high (score ≥ 4 points) risk. We investigated the relationship between NLRP3 inflammasome and laboratory indicators. Additionally, we examined whether the NLRP3 inflammasome was an independent predictor of high TRS-2P and explored the applicability of the plasma NLRP3 inflammasome for predicting high TRS-2P.Results: Logistic regression analysis revealed that NLRP3 inflammasome was an independent predictor of high TRS-2P (odds ratio [OR]:2.013; 95% confidence interval [CI]: 1.174– 3.452). The area under the receiver operating characteristic curve value of the NLRP3 inflammasome was 0.674 (95% CI: 0.611– 0.737; P < 0.001).Conclusion: NLRP3 inflammasome levels are an independent predictive factor for high TRS-2P levels, which indicates that the NLRP3 inflammasome may help predict the prognosis of ACS patients.Keywords: NLRP3 inflammasome, biomarker, risk stratification, acute coronary syndrome, thrombolysis in myocardial infarction risk score for secondary prevention, TRS-2P |
| first_indexed | 2024-04-11T06:19:36Z |
| format | Article |
| id | doaj.art-5d12a67cbf8446a0b32a763982db1bb1 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-04-11T06:19:36Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-5d12a67cbf8446a0b32a763982db1bb12022-12-22T04:40:51ZengDove Medical PressJournal of Inflammation Research1178-70312022-12-01Volume 156595660580113NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary SyndromeMo DGWang LHan QFYu KLiu JHYao HCDe-Gang Mo,1 Lin Wang,2 Qian-Feng Han,1 Kang Yu,3 Jia-Hui Liu,1 Heng-Chen Yao1 1Department of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, People’s Republic of China; 2Cardiologic Color Doppler Room, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, People’s Republic of China; 3Department of Laboratory Medicine, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, People’s Republic of ChinaCorrespondence : Heng-Chen YaoDepartment of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, 252000, People’s Republic of China, Email yaohc66@126.comPurpose: Acute coronary syndrome (ACS) has a high incidence and mortality rate worldwide, which has a considerable negative impact on the global economy. This study aimed to identify a group of ACS patients at a high risk of recurrent adverse cardiac events using the plasma NLRP3 inflammasome.Patients and methods: ACS patients admitted to Liaocheng People’s Hospital between June 2021 and March 2022 were enrolled in this study. Patients were divided into low (levels < 3.84 ng/mL) and high (levels ≥ 3.84 ng/mL) groups based on the median NLRP3 inflammasome levels. The patients were divided into three groups according to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention (TRS-2P): low (scores ≤ 2 points), intermediate (scores = 3 points), and high (score ≥ 4 points) risk. We investigated the relationship between NLRP3 inflammasome and laboratory indicators. Additionally, we examined whether the NLRP3 inflammasome was an independent predictor of high TRS-2P and explored the applicability of the plasma NLRP3 inflammasome for predicting high TRS-2P.Results: Logistic regression analysis revealed that NLRP3 inflammasome was an independent predictor of high TRS-2P (odds ratio [OR]:2.013; 95% confidence interval [CI]: 1.174– 3.452). The area under the receiver operating characteristic curve value of the NLRP3 inflammasome was 0.674 (95% CI: 0.611– 0.737; P < 0.001).Conclusion: NLRP3 inflammasome levels are an independent predictive factor for high TRS-2P levels, which indicates that the NLRP3 inflammasome may help predict the prognosis of ACS patients.Keywords: NLRP3 inflammasome, biomarker, risk stratification, acute coronary syndrome, thrombolysis in myocardial infarction risk score for secondary prevention, TRS-2Phttps://www.dovepress.com/nlrp3-inflammasome-may-be-a-biomarker-for-risk-stratification-in-patie-peer-reviewed-fulltext-article-JIRnlrp3 inflammasomebiomarkerrisk stratificationacute coronary syndromethrombolysis in myocardial infarction risk score for secondary preventiontrs-2p |
| spellingShingle | Mo DG Wang L Han QF Yu K Liu JH Yao HC NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome Journal of Inflammation Research nlrp3 inflammasome biomarker risk stratification acute coronary syndrome thrombolysis in myocardial infarction risk score for secondary prevention trs-2p |
| title | NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome |
| title_full | NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome |
| title_fullStr | NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome |
| title_full_unstemmed | NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome |
| title_short | NLRP3 Inflammasome May Be a Biomarker for Risk Stratification in Patients with Acute Coronary Syndrome |
| title_sort | nlrp3 inflammasome may be a biomarker for risk stratification in patients with acute coronary syndrome |
| topic | nlrp3 inflammasome biomarker risk stratification acute coronary syndrome thrombolysis in myocardial infarction risk score for secondary prevention trs-2p |
| url | https://www.dovepress.com/nlrp3-inflammasome-may-be-a-biomarker-for-risk-stratification-in-patie-peer-reviewed-fulltext-article-JIR |
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