Selective suppression of leukocyte recruitment in allergic inflammation
Allergic diseases result in a considerable socioeconomic burden. The incidence of allergic diseases, notably allergic asthma, has risen to high levels for reasons that are not entirely understood. With an increasing knowledge of underlying mechanisms, there is now more potential to target the inflam...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2005-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900026 |
| _version_ | 1797712602045874176 |
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| author | CL Weller PJ Jose TJ Williams |
| author_facet | CL Weller PJ Jose TJ Williams |
| author_sort | CL Weller |
| collection | DOAJ |
| description | Allergic diseases result in a considerable socioeconomic burden. The incidence of allergic diseases, notably allergic asthma, has risen to high levels for reasons that are not entirely understood. With an increasing knowledge of underlying mechanisms, there is now more potential to target the inflammatory process rather than the overt symptoms. This focuses attention on the role of leukocytes especially Th2 lymphocytes that regulate allergic inflammation and effector cells where eosinophils have received much attention. Eosinophils are thought to be important based on the high numbers that are recruited to sites of allergic inflammation and the potential of these cells to effect both tissue injury and remodelling. It is hoped that future therapy will be directed towards specific leukocyte types, without overtly compromising essential host defence responses. One obvious target is leukocyte recruitment. This necessitates a detailed understanding of underlying mechanisms, particularly those involving soluble che-moattractants signals and cell-cell adhesion molecules. |
| first_indexed | 2024-03-12T07:23:12Z |
| format | Article |
| id | doaj.art-5d150bd9b74445ab89ef79d71ba65798 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:23:12Z |
| publishDate | 2005-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-5d150bd9b74445ab89ef79d71ba657982023-09-02T22:14:57ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602005-03-0110015316010.1590/S0074-02762005000900026Selective suppression of leukocyte recruitment in allergic inflammationCL WellerPJ JoseTJ WilliamsAllergic diseases result in a considerable socioeconomic burden. The incidence of allergic diseases, notably allergic asthma, has risen to high levels for reasons that are not entirely understood. With an increasing knowledge of underlying mechanisms, there is now more potential to target the inflammatory process rather than the overt symptoms. This focuses attention on the role of leukocytes especially Th2 lymphocytes that regulate allergic inflammation and effector cells where eosinophils have received much attention. Eosinophils are thought to be important based on the high numbers that are recruited to sites of allergic inflammation and the potential of these cells to effect both tissue injury and remodelling. It is hoped that future therapy will be directed towards specific leukocyte types, without overtly compromising essential host defence responses. One obvious target is leukocyte recruitment. This necessitates a detailed understanding of underlying mechanisms, particularly those involving soluble che-moattractants signals and cell-cell adhesion molecules.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900026allergyleukocyteseosinophilschemokinesinterleukin-5 |
| spellingShingle | CL Weller PJ Jose TJ Williams Selective suppression of leukocyte recruitment in allergic inflammation Memorias do Instituto Oswaldo Cruz allergy leukocytes eosinophils chemokines interleukin-5 |
| title | Selective suppression of leukocyte recruitment in allergic inflammation |
| title_full | Selective suppression of leukocyte recruitment in allergic inflammation |
| title_fullStr | Selective suppression of leukocyte recruitment in allergic inflammation |
| title_full_unstemmed | Selective suppression of leukocyte recruitment in allergic inflammation |
| title_short | Selective suppression of leukocyte recruitment in allergic inflammation |
| title_sort | selective suppression of leukocyte recruitment in allergic inflammation |
| topic | allergy leukocytes eosinophils chemokines interleukin-5 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900026 |
| work_keys_str_mv | AT clweller selectivesuppressionofleukocyterecruitmentinallergicinflammation AT pjjose selectivesuppressionofleukocyterecruitmentinallergicinflammation AT tjwilliams selectivesuppressionofleukocyterecruitmentinallergicinflammation |