The Clinical Value of Axillary Ultrasonogra- phy for Detection of Axillary Lymph Node Metastasis in Cases with Breast Cancer
Background: The axillary lymph node stage is one of the single most important determinants in the prognosis of breast cancer patients. The disadvantages of the two previous methods used for evaluating axillary node metastasis, i.e., axillary lymph node dissection and sentinel lymph node biopsy, have...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2014-10-01
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| Series: | Middle East Journal of Cancer |
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| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/155/144 |
| _version_ | 1818120062696947712 |
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| author | Sedigheh Tahmasebi Behnam Dalfardi Majid Akrami Arash Talei Abdolrasoul Talei Alireza Rasekhi |
| author_facet | Sedigheh Tahmasebi Behnam Dalfardi Majid Akrami Arash Talei Abdolrasoul Talei Alireza Rasekhi |
| author_sort | Sedigheh Tahmasebi |
| collection | DOAJ |
| description | Background: The axillary lymph node stage is one of the single most important determinants in the prognosis of breast cancer patients. The disadvantages of the two previous methods used for evaluating axillary node metastasis, i.e., axillary lymph node dissection and sentinel lymph node biopsy, have directed researchers to investigate new techniques for this purpose. The aim of the current study was to evaluate the clinical usefulness of axillary ultrasonography in detecting axillary metastasis.
Methods: This study was conducted during a 12-month period. The breast cancer cases included in this study were all clinically diagnosed as stages I and II, with no prior treatment to the axillary region by surgery and/or chemo-radiotherapy. Excluded from the study group were patients with palpable axillary lymph nodes, those who had major organ failure or concomitant malignancy. All included patients with non-palpable axillary lymph nodes underwent axillary ultrasound examination. An ultrasound- guided core needle biopsy was performed on patients with suspected metastasis.
Results: There were 125 female patients with a mean age of 49.6 years included in this study. From these, 16 (12.8%) cases had positive axillary sonographic findings. Pathologic evaluation of tissue specimens (taken by ultrasound-guided core needle biopsy) in 10 (62.5%) out of 16 patients were positive, and in the patient group of 6 (37.5%) cases, studies were negative. Axillary ultrasonography had a sensitivity of 35.7%, specificity of 93.8%, positive predictive value of 62.5%, and negative predictive value of 83.5%.
Conclusion: The axillary ultrasonogram is a reliable technique in the determination of axillary nodal metastatic involvement in breast cancer patients. By use of this method a significant amount of complications and costs related to the previous techniques can be avoided. |
| first_indexed | 2024-12-11T05:20:07Z |
| format | Article |
| id | doaj.art-5d158cd7b0524ec8b40c8aeb44a525bc |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-11T05:20:07Z |
| publishDate | 2014-10-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-5d158cd7b0524ec8b40c8aeb44a525bc2022-12-22T01:19:43ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872014-10-0154215220The Clinical Value of Axillary Ultrasonogra- phy for Detection of Axillary Lymph Node Metastasis in Cases with Breast CancerSedigheh Tahmasebi0 Behnam Dalfardi1 Majid Akrami2 Arash Talei3Abdolrasoul Talei4 Alireza Rasekhi5Department of Surgery, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Surgery, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Radiology, Shiraz University of Medical Sciences, Shiraz, IranBackground: The axillary lymph node stage is one of the single most important determinants in the prognosis of breast cancer patients. The disadvantages of the two previous methods used for evaluating axillary node metastasis, i.e., axillary lymph node dissection and sentinel lymph node biopsy, have directed researchers to investigate new techniques for this purpose. The aim of the current study was to evaluate the clinical usefulness of axillary ultrasonography in detecting axillary metastasis. Methods: This study was conducted during a 12-month period. The breast cancer cases included in this study were all clinically diagnosed as stages I and II, with no prior treatment to the axillary region by surgery and/or chemo-radiotherapy. Excluded from the study group were patients with palpable axillary lymph nodes, those who had major organ failure or concomitant malignancy. All included patients with non-palpable axillary lymph nodes underwent axillary ultrasound examination. An ultrasound- guided core needle biopsy was performed on patients with suspected metastasis. Results: There were 125 female patients with a mean age of 49.6 years included in this study. From these, 16 (12.8%) cases had positive axillary sonographic findings. Pathologic evaluation of tissue specimens (taken by ultrasound-guided core needle biopsy) in 10 (62.5%) out of 16 patients were positive, and in the patient group of 6 (37.5%) cases, studies were negative. Axillary ultrasonography had a sensitivity of 35.7%, specificity of 93.8%, positive predictive value of 62.5%, and negative predictive value of 83.5%. Conclusion: The axillary ultrasonogram is a reliable technique in the determination of axillary nodal metastatic involvement in breast cancer patients. By use of this method a significant amount of complications and costs related to the previous techniques can be avoided.http://mejc.sums.ac.ir/index.php/mejc/article/view/155/144AxillaBiopsyBreast neoplasmsLymph nodesNeoplasm metastasisUltra- sonography |
| spellingShingle | Sedigheh Tahmasebi Behnam Dalfardi Majid Akrami Arash Talei Abdolrasoul Talei Alireza Rasekhi The Clinical Value of Axillary Ultrasonogra- phy for Detection of Axillary Lymph Node Metastasis in Cases with Breast Cancer Middle East Journal of Cancer Axilla Biopsy Breast neoplasms Lymph nodes Neoplasm metastasis Ultra- sonography |
| title | The Clinical Value of Axillary Ultrasonogra- phy for Detection of Axillary Lymph Node Metastasis in Cases with Breast Cancer |
| title_full | The Clinical Value of Axillary Ultrasonogra- phy for Detection of Axillary Lymph Node Metastasis in Cases with Breast Cancer |
| title_fullStr | The Clinical Value of Axillary Ultrasonogra- phy for Detection of Axillary Lymph Node Metastasis in Cases with Breast Cancer |
| title_full_unstemmed | The Clinical Value of Axillary Ultrasonogra- phy for Detection of Axillary Lymph Node Metastasis in Cases with Breast Cancer |
| title_short | The Clinical Value of Axillary Ultrasonogra- phy for Detection of Axillary Lymph Node Metastasis in Cases with Breast Cancer |
| title_sort | clinical value of axillary ultrasonogra phy for detection of axillary lymph node metastasis in cases with breast cancer |
| topic | Axilla Biopsy Breast neoplasms Lymph nodes Neoplasm metastasis Ultra- sonography |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/155/144 |
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