Mallotucin D, a Clerodane Diterpenoid from <i>Croton crassifolius</i>, Suppresses HepG2 Cell Growth via Inducing Autophagic Cell Death and Pyroptosis

Mallotucin D, a Clerodane Diterpenoid from <i>Croton crassifolius</i>, Suppresses HepG2 Cell Growth via Inducing Autophagic Cell Death and Pyroptosis

Hepatocellular carcinoma (HCC) is a major subtype of primary liver cancer with a high mortality rate. Pyroptosis and autophagy are crucial processes in the pathophysiology of HCC. Searching for efficient drugs targeting pyroptosis and autophagy with lower toxicity is useful for HCC treatment. Mallot...

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Bibliographic Details
Main Authors: Xiaoyong Dai, Fen Sun, Kexin Deng, Gaoyang Lin, Wenjing Yin, Huaqing Chen, Dongye Yang, Kewei Liu, Yubo Zhang, Laiqiang Huang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
HepG2 cell
mallotucin D
ROS
mitophagy
pyroptosis
BNIP3
Online Access:https://www.mdpi.com/1422-0067/23/22/14217

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