The microbiome-gut-brain axis in multiple sclerosis
The microbiome-gut-brain axis (MGBA) represents a close two-way relationship between the gut and the central nervous system (CNS) mediated by the immune system, the enteric nervous system (ENS), the vagus nerve, and the gut microbiome. Gut microbes, including bacteria, fungi, and viruses, can commun...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2023-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2023/0004-19632306441R.pdf |
| _version_ | 1797366948639539200 |
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| author | Radojević Dušan Soković-Bajić Svetlana Dinić Miroslav Bisenić Aleksandar Đokić Jelena Golić Nataša |
| author_facet | Radojević Dušan Soković-Bajić Svetlana Dinić Miroslav Bisenić Aleksandar Đokić Jelena Golić Nataša |
| author_sort | Radojević Dušan |
| collection | DOAJ |
| description | The microbiome-gut-brain axis (MGBA) represents a close two-way relationship between the gut and the central nervous system (CNS) mediated by the immune system, the enteric nervous system (ENS), the vagus nerve, and the gut microbiome. Gut microbes, including bacteria, fungi, and viruses, can communicate with the CNS and modulate the physiology of the brain in health and disease, which marks them as an important MGBA factor. It is becoming increasingly evident that gut microbiome dysbiosis is implicated in the onset and severity of different neurodegenerative and psychiatric diseases including multiple sclerosis (MS). MS is a chronic disease of the CNS associated with different genetic and environmental risk factors. Neuroinflammation and demyelination in the brain and the spinal cord are hallmark features of MS. The accumulating evidence shows that the MGBA, although a relatively new concept, has an important role in MS. Therefore, the purpose of this article is to review recent research on the gut-brain connection in MS, and to highlight MS-associated gut microbiota constituents and the role of bacterial metabolites in MS. |
| first_indexed | 2024-03-08T17:11:46Z |
| format | Article |
| id | doaj.art-5d15e424c3b64fac894faa56abc28d92 |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-03-08T17:11:46Z |
| publishDate | 2023-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-5d15e424c3b64fac894faa56abc28d922024-01-03T21:27:34ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672023-01-0173644146210.5937/arhfarm73-469860004-19632306441RThe microbiome-gut-brain axis in multiple sclerosisRadojević Dušan0Soković-Bajić Svetlana1Dinić Miroslav2Bisenić Aleksandar3Đokić Jelena4Golić Nataša5https://orcid.org/0000-0001-7419-9743Institute of Molecular Genetics and Genetic Engineering, Group for Probiotics and Microbiota-Host Interaction, Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, Group for Probiotics and Microbiota-Host Interaction, Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, Group for Probiotics and Microbiota-Host Interaction, Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, Group for Probiotics and Microbiota-Host Interaction, Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, Group for Probiotics and Microbiota-Host Interaction, Belgrade, SerbiaInstitute of Molecular Genetics and Genetic Engineering, Group for Probiotics and Microbiota-Host Interaction, Belgrade, SerbiaThe microbiome-gut-brain axis (MGBA) represents a close two-way relationship between the gut and the central nervous system (CNS) mediated by the immune system, the enteric nervous system (ENS), the vagus nerve, and the gut microbiome. Gut microbes, including bacteria, fungi, and viruses, can communicate with the CNS and modulate the physiology of the brain in health and disease, which marks them as an important MGBA factor. It is becoming increasingly evident that gut microbiome dysbiosis is implicated in the onset and severity of different neurodegenerative and psychiatric diseases including multiple sclerosis (MS). MS is a chronic disease of the CNS associated with different genetic and environmental risk factors. Neuroinflammation and demyelination in the brain and the spinal cord are hallmark features of MS. The accumulating evidence shows that the MGBA, although a relatively new concept, has an important role in MS. Therefore, the purpose of this article is to review recent research on the gut-brain connection in MS, and to highlight MS-associated gut microbiota constituents and the role of bacterial metabolites in MS.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2023/0004-19632306441R.pdfgut microbiomemultiple sclerosisgut-brain axisbacterial metabolitesdysbiosis |
| spellingShingle | Radojević Dušan Soković-Bajić Svetlana Dinić Miroslav Bisenić Aleksandar Đokić Jelena Golić Nataša The microbiome-gut-brain axis in multiple sclerosis Arhiv za farmaciju gut microbiome multiple sclerosis gut-brain axis bacterial metabolites dysbiosis |
| title | The microbiome-gut-brain axis in multiple sclerosis |
| title_full | The microbiome-gut-brain axis in multiple sclerosis |
| title_fullStr | The microbiome-gut-brain axis in multiple sclerosis |
| title_full_unstemmed | The microbiome-gut-brain axis in multiple sclerosis |
| title_short | The microbiome-gut-brain axis in multiple sclerosis |
| title_sort | microbiome gut brain axis in multiple sclerosis |
| topic | gut microbiome multiple sclerosis gut-brain axis bacterial metabolites dysbiosis |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2023/0004-19632306441R.pdf |
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