Guanylate-Binding Proteins Are Critical for Effective Control of Francisella tularensis Strains in a Mouse Co-Culture System of Adaptive Immunity

Guanylate-Binding Proteins Are Critical for Effective Control of Francisella tularensis Strains in a Mouse Co-Culture System of Adaptive Immunity

Francisella tularensis is a Select Agent that causes the severe disease tularemia in humans and many animal species. The bacterium demonstrates rapid intracellular replication, however, macrophages can control its replication if primed and activation with IFN-γ is known to be essential, although alo...

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Bibliographic Details
Main Authors: Nasibeh Mohammadi, Helena Lindgren, Igor Golovliov, Kjell Eneslätt, Masahiro Yamamoto, Amandine Martin, Thomas Henry, Anders Sjöstedt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Francisella tularensis
guanylate-binding proteins
mouse co-culture model
cytokine patterns
correlates of protection
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.594063/full

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