Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study

Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study

Abstract Background Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing of antimicrobial therapy is of central importance to improve outcome. Liver failure may alter antibiotic drug concentrations via changes of drug distribution and elimination. We studie...

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Bibliographic Details
Main Authors: Jörn Grensemann, David Busse, Christina König, Kevin Roedl, Walter Jäger, Dominik Jarczak, Stefanie Iwersen-Bergmann, Carolin Manthey, Stefan Kluge, Charlotte Kloft, Valentin Fuhrmann
Format: Article
Language:English
Published: SpringerOpen 2020-04-01
Series:Annals of Intensive Care
Subjects:
Antibiotics
Target attainment
Intensive care
Volume of distribution
Monte Carlo simulation
Population pharmacokinetics
Online Access:http://link.springer.com/article/10.1186/s13613-020-00666-8

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