Proof of concept in non-human primates of the heterologous prime-boost strategy combining dengue-2 virus and recombinant proteins including domain III of the viral envelope protein

Proof of concept in non-human primates of the heterologous prime-boost strategy combining dengue-2 virus and recombinant proteins including domain III of the viral envelope protein

Live attenuated viruses are the most advanced candidates against a dengue infection. They have been demonstrated to be immunogenic in preclinical and clinical studies. However, due to their replicative capacity, they require several doses to achieve the balanced immune response against the four sero...

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Bibliographic Details
Main Authors: Iris Valdés, Lisset Hermida, Lázaro Gil, Laura Lazo1, Gerardo Guillén, María G Guzmán, Jorge Castro, Yaremis Romero, Pedro Puente, Jorge Martín, Ernesto Marcos, Carlos López, Jorge Sánchez, Olivia Niebla, Tamara Menéndez, Alienys Izquierdo, Edith Suzarte, José A Silva
Format: Article
Language:English
Published: Elfos Scientiae
Series:Biotecnología Aplicada
Subjects:
dengue
vaccine candidate
prime-boost
neutralizing antibodies
non-human primates
Online Access:http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522013000200010&lng=en&tlng=en

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