Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control
Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scaveng...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/4/354 |
| _version_ | 1797538534751469568 |
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| author | Chia-Ming Su Raymond Robert Richard Rowland Dongwan Yoo |
| author_facet | Chia-Ming Su Raymond Robert Richard Rowland Dongwan Yoo |
| author_sort | Chia-Ming Su |
| collection | DOAJ |
| description | Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and understanding of the entry of PRRSV into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor–ligand for the control of PRRS. |
| first_indexed | 2024-03-10T12:32:48Z |
| format | Article |
| id | doaj.art-5d1dfe9d94b7429591aea9f33a697b91 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T12:32:48Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-5d1dfe9d94b7429591aea9f33a697b912023-11-21T14:29:26ZengMDPI AGVaccines2076-393X2021-04-019435410.3390/vaccines9040354Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for ControlChia-Ming Su0Raymond Robert Richard Rowland1Dongwan Yoo2Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USADepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USADepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USACellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and understanding of the entry of PRRSV into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor–ligand for the control of PRRS.https://www.mdpi.com/2076-393X/9/4/354porcine reproductive and respiratory syndromereceptorPRRSVCD163 |
| spellingShingle | Chia-Ming Su Raymond Robert Richard Rowland Dongwan Yoo Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control Vaccines porcine reproductive and respiratory syndrome receptor PRRSV CD163 |
| title | Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control |
| title_full | Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control |
| title_fullStr | Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control |
| title_full_unstemmed | Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control |
| title_short | Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control |
| title_sort | recent advances in prrs virus receptors and the targeting of receptor ligand for control |
| topic | porcine reproductive and respiratory syndrome receptor PRRSV CD163 |
| url | https://www.mdpi.com/2076-393X/9/4/354 |
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