Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
This paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2013-07-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.9.160 |
| _version_ | 1818617099412570112 |
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| author | Cybille Rossy Eric Fouquet François-Xavier Felpin |
| author_facet | Cybille Rossy Eric Fouquet François-Xavier Felpin |
| author_sort | Cybille Rossy |
| collection | DOAJ |
| description | This paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows the preparation of heterocycles with good yields and is tolerant to a wide variety of functional groups. |
| first_indexed | 2024-12-16T17:00:19Z |
| format | Article |
| id | doaj.art-5d1f49e032b74d0e90bf193b799b14f8 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-16T17:00:19Z |
| publishDate | 2013-07-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-5d1f49e032b74d0e90bf193b799b14f82022-12-21T22:23:46ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972013-07-01911426143110.3762/bjoc.9.1601860-5397-9-160Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalystCybille Rossy0Eric Fouquet1François-Xavier Felpin2Université de Bordeaux, UMR CNRS 5255, ISM, 351 cours de la Libération, 33405 Talence Cedex, FranceUniversité de Bordeaux, UMR CNRS 5255, ISM, 351 cours de la Libération, 33405 Talence Cedex, FranceUniversité de Nantes, UFR Sciences et Techniques, UMR CNRS 6230, CEISAM, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, FranceThis paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows the preparation of heterocycles with good yields and is tolerant to a wide variety of functional groups.https://doi.org/10.3762/bjoc.9.160benzofuranbimetallic catalystheterogeneous catalysisindolewater |
| spellingShingle | Cybille Rossy Eric Fouquet François-Xavier Felpin Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst Beilstein Journal of Organic Chemistry benzofuran bimetallic catalyst heterogeneous catalysis indole water |
| title | Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst |
| title_full | Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst |
| title_fullStr | Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst |
| title_full_unstemmed | Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst |
| title_short | Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst |
| title_sort | practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst |
| topic | benzofuran bimetallic catalyst heterogeneous catalysis indole water |
| url | https://doi.org/10.3762/bjoc.9.160 |
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