Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study
(1) Background. Multiple sclerosis (MS) is characterised by the loss of muscle throughout the course of the disease, which in many cases is accompanied by obesity and related to inflammation. Nonetheless, consuming epigallocatechin gallate (EGCG) and ketone bodies (especially β-hydroxybutyrate (βHB)...
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MDPI AG
2021-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/9/3230 |
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| author | Jose Enrique de la Rubia Ortí Jose Luis Platero Iván Hu Yang Jose Joaquin Ceron Asta Tvarijonaviciute Pablo Selvi Sabater María Benlloch David Sancho-Cantus Sandra Sancho |
| author_facet | Jose Enrique de la Rubia Ortí Jose Luis Platero Iván Hu Yang Jose Joaquin Ceron Asta Tvarijonaviciute Pablo Selvi Sabater María Benlloch David Sancho-Cantus Sandra Sancho |
| author_sort | Jose Enrique de la Rubia Ortí |
| collection | DOAJ |
| description | (1) Background. Multiple sclerosis (MS) is characterised by the loss of muscle throughout the course of the disease, which in many cases is accompanied by obesity and related to inflammation. Nonetheless, consuming epigallocatechin gallate (EGCG) and ketone bodies (especially β-hydroxybutyrate (βHB)) produced after metabolising coconut oil, have exhibited anti-inflammatory effects and a decrease in body fat. In addition, butyrylcholinesterase (BuChE), seems to be related to the pathogenesis of the disease associated with inflammation, and serum concentrations have been related to lipid metabolism. Objective. The aim of the study was to determine the role of BuChE in the changes caused after treatment with EGCG and ketone bodies on the levels of body fat and inflammation state in MS patients. (2) Methods. A pilot study was conducted for 4 months with 51 MS patients who were randomly divided into an intervention group and a control group. The intervention group received 800 mg of EGCG and 60 mL of coconut oil, and the control group was prescribed a placebo. Fat percentage and concentrations of the butyrylcholinesterase enzyme (BuChE), paraoxonase 1 (PON1) activity, triglycerides, interleukin 6 (IL-6), albumin and βHB in serum were measured. (3) Results. The intervention group exhibited significant decreases in IL-6 and fat percentage and significant increases in BuChE, βHB, PON1, albumin and functional capacity (determined by the Expanded Disability Status Scale (EDSS)). On the other hand, the control group only exhibited a decrease in IL-6. After the intervention, BuChE was positively correlated with the activity of PON1, fat percentage and triglycerides in the intervention group, whereas these correlations were not observed in the control group (4). Conclusions. BuChE seems to have an important role in lipolytic activity and the inflammation state in MS patients, evidenced after administering EGCG and coconut oil as a βHB source. |
| first_indexed | 2024-03-10T07:20:13Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T07:20:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-5d224ce87a20460497403b41d47e46782023-11-22T14:39:22ZengMDPI AGNutrients2072-66432021-09-01139323010.3390/nu13093230Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot StudyJose Enrique de la Rubia Ortí0Jose Luis Platero1Iván Hu Yang2Jose Joaquin Ceron3Asta Tvarijonaviciute4Pablo Selvi Sabater5María Benlloch6David Sancho-Cantus7Sandra Sancho8Department of Nursing, Catholic University San Vicente Mártir, 46001 Valencia, SpainDoctoral Degree School, Catholic University of Valencia, 46001 Valencia, SpainDepartment of Nursing, Catholic University San Vicente Mártir, 46001 Valencia, SpainInterdisciplinary Laboratory of Clinical Analysis, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Murcia, SpainInterdisciplinary Laboratory of Clinical Analysis, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Murcia, SpainHospital de La Plana, 12540 Villareal, SpainDepartment of Nursing, Catholic University San Vicente Mártir, 46001 Valencia, SpainDepartment of Nursing, Catholic University San Vicente Mártir, 46001 Valencia, SpainDepartment of Nursing, Catholic University San Vicente Mártir, 46001 Valencia, Spain(1) Background. Multiple sclerosis (MS) is characterised by the loss of muscle throughout the course of the disease, which in many cases is accompanied by obesity and related to inflammation. Nonetheless, consuming epigallocatechin gallate (EGCG) and ketone bodies (especially β-hydroxybutyrate (βHB)) produced after metabolising coconut oil, have exhibited anti-inflammatory effects and a decrease in body fat. In addition, butyrylcholinesterase (BuChE), seems to be related to the pathogenesis of the disease associated with inflammation, and serum concentrations have been related to lipid metabolism. Objective. The aim of the study was to determine the role of BuChE in the changes caused after treatment with EGCG and ketone bodies on the levels of body fat and inflammation state in MS patients. (2) Methods. A pilot study was conducted for 4 months with 51 MS patients who were randomly divided into an intervention group and a control group. The intervention group received 800 mg of EGCG and 60 mL of coconut oil, and the control group was prescribed a placebo. Fat percentage and concentrations of the butyrylcholinesterase enzyme (BuChE), paraoxonase 1 (PON1) activity, triglycerides, interleukin 6 (IL-6), albumin and βHB in serum were measured. (3) Results. The intervention group exhibited significant decreases in IL-6 and fat percentage and significant increases in BuChE, βHB, PON1, albumin and functional capacity (determined by the Expanded Disability Status Scale (EDSS)). On the other hand, the control group only exhibited a decrease in IL-6. After the intervention, BuChE was positively correlated with the activity of PON1, fat percentage and triglycerides in the intervention group, whereas these correlations were not observed in the control group (4). Conclusions. BuChE seems to have an important role in lipolytic activity and the inflammation state in MS patients, evidenced after administering EGCG and coconut oil as a βHB source.https://www.mdpi.com/2072-6643/13/9/3230multiple sclerosisEGCGβ-hydroxybutyratebutyrylcholinesteraseinflammation |
| spellingShingle | Jose Enrique de la Rubia Ortí Jose Luis Platero Iván Hu Yang Jose Joaquin Ceron Asta Tvarijonaviciute Pablo Selvi Sabater María Benlloch David Sancho-Cantus Sandra Sancho Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study Nutrients multiple sclerosis EGCG β-hydroxybutyrate butyrylcholinesterase inflammation |
| title | Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study |
| title_full | Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study |
| title_fullStr | Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study |
| title_full_unstemmed | Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study |
| title_short | Possible Role of Butyrylcholinesterase in Fat Loss and Decreases in Inflammatory Levels in Patients with Multiple Sclerosis after Treatment with Epigallocatechin Gallate and Coconut Oil: A Pilot Study |
| title_sort | possible role of butyrylcholinesterase in fat loss and decreases in inflammatory levels in patients with multiple sclerosis after treatment with epigallocatechin gallate and coconut oil a pilot study |
| topic | multiple sclerosis EGCG β-hydroxybutyrate butyrylcholinesterase inflammation |
| url | https://www.mdpi.com/2072-6643/13/9/3230 |
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