Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study
Aims: Cases of infectious uveitis in immunodeficient patients may present with atypical clinical features because the clinical course of disease is usually affected by the compromised immune system. Therefore, it is sometimes difficult to determine the correct diagnosis. The aim of this study was to...
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| Format: | Article |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2020-12-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202004-0009_infectious-uveitis-in-immunodeficient-hiv-negative-patients-a-retrospective-study.php |
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| author | Petra Svozilkova Eva Rihova Michaela Brichova Andrea Havlikova Aneta Klimova Jarmila Heissigerova |
| author_facet | Petra Svozilkova Eva Rihova Michaela Brichova Andrea Havlikova Aneta Klimova Jarmila Heissigerova |
| author_sort | Petra Svozilkova |
| collection | DOAJ |
| description | Aims: Cases of infectious uveitis in immunodeficient patients may present with atypical clinical features because the clinical course of disease is usually affected by the compromised immune system. Therefore, it is sometimes difficult to determine the correct diagnosis. The aim of this study was to evaluate a prevalence of immunodeficient HIV-negative individuals among patients with infectious uveitis and to assess diagnostic and therapeutic approaches. Methods: A retrospective study. Results: In years 2003-2017, we diagnosed 594 patients with infectious uveitis. In 35 of them, infectious uveitis occurred on the basis of immunodeficiency (malignancy, immunosuppressive therapy etc.). The most common infectious uveitis was cytomegalovirus retinitis, followed by acute retinal necrosis, herpetic anterior uveitis, endogenous fungal endophthalmitis, toxoplasmic retinochoroiditis, progressive outer retinal necrosis and syphilis. In indicated cases, intraocular fluid examination was a valuable diagnostic tool. After initiation of treatment, improvement of BCVA was observed in 13 eyes, stabilization in 13 eyes and deterioration in 11 eyes. In some patients who experienced adverse effects of medication, the recommended doses were decreased. Conclusion: Our experience shows that patients with diagnoses of acute retinal necrosis or progressive outer retinal necrosis have a poor visual prognosis. The occurrence of cytomegalovirus retinitis signifies a very unfavorable survival prognosis in patients who underwent hematopoietic stem cell transplantation; the patients in our study died within 1 year from cytomegalovirus retinitis diagnosis. |
| first_indexed | 2024-12-20T06:02:42Z |
| format | Article |
| id | doaj.art-5d231ac432964e05bc18aadc4718f91f |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-20T06:02:42Z |
| publishDate | 2020-12-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-5d231ac432964e05bc18aadc4718f91f2022-12-21T19:50:53ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212020-12-01164441041610.5507/bp.2019.036bio-202004-0009Infectious uveitis in immunodeficient HIV-negative patients: A retrospective studyPetra Svozilkova0Eva Rihova1Michaela Brichova2Andrea Havlikova3Aneta Klimova4Jarmila Heissigerova5Department of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech RepublicDepartment of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech RepublicDepartment of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech RepublicDepartment of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech RepublicDepartment of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech RepublicDepartment of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech RepublicAims: Cases of infectious uveitis in immunodeficient patients may present with atypical clinical features because the clinical course of disease is usually affected by the compromised immune system. Therefore, it is sometimes difficult to determine the correct diagnosis. The aim of this study was to evaluate a prevalence of immunodeficient HIV-negative individuals among patients with infectious uveitis and to assess diagnostic and therapeutic approaches. Methods: A retrospective study. Results: In years 2003-2017, we diagnosed 594 patients with infectious uveitis. In 35 of them, infectious uveitis occurred on the basis of immunodeficiency (malignancy, immunosuppressive therapy etc.). The most common infectious uveitis was cytomegalovirus retinitis, followed by acute retinal necrosis, herpetic anterior uveitis, endogenous fungal endophthalmitis, toxoplasmic retinochoroiditis, progressive outer retinal necrosis and syphilis. In indicated cases, intraocular fluid examination was a valuable diagnostic tool. After initiation of treatment, improvement of BCVA was observed in 13 eyes, stabilization in 13 eyes and deterioration in 11 eyes. In some patients who experienced adverse effects of medication, the recommended doses were decreased. Conclusion: Our experience shows that patients with diagnoses of acute retinal necrosis or progressive outer retinal necrosis have a poor visual prognosis. The occurrence of cytomegalovirus retinitis signifies a very unfavorable survival prognosis in patients who underwent hematopoietic stem cell transplantation; the patients in our study died within 1 year from cytomegalovirus retinitis diagnosis.https://biomed.papers.upol.cz/artkey/bio-202004-0009_infectious-uveitis-in-immunodeficient-hiv-negative-patients-a-retrospective-study.phpherpetic retinal necrosiscytomegalovirus retinitisimmunodeficiencyfungal endophthalmitistoxoplasmic retinochoroiditis |
| spellingShingle | Petra Svozilkova Eva Rihova Michaela Brichova Andrea Havlikova Aneta Klimova Jarmila Heissigerova Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study Biomedical Papers herpetic retinal necrosis cytomegalovirus retinitis immunodeficiency fungal endophthalmitis toxoplasmic retinochoroiditis |
| title | Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study |
| title_full | Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study |
| title_fullStr | Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study |
| title_full_unstemmed | Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study |
| title_short | Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study |
| title_sort | infectious uveitis in immunodeficient hiv negative patients a retrospective study |
| topic | herpetic retinal necrosis cytomegalovirus retinitis immunodeficiency fungal endophthalmitis toxoplasmic retinochoroiditis |
| url | https://biomed.papers.upol.cz/artkey/bio-202004-0009_infectious-uveitis-in-immunodeficient-hiv-negative-patients-a-retrospective-study.php |
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