Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications
The peripheral nervous system undergoes sufficient stress when affected by diabetic conditions, chemotherapeutic drugs, and personal injury. Consequently, peripheral neuropathy arises as the most common complication, leading to debilitating symptoms that significantly alter the quality and way of li...
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/3/489 |
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| author | Danyale Berry Justice Ene Aakash Nathani Mandip Singh Yan Li Changchun Zeng |
| author_facet | Danyale Berry Justice Ene Aakash Nathani Mandip Singh Yan Li Changchun Zeng |
| author_sort | Danyale Berry |
| collection | DOAJ |
| description | The peripheral nervous system undergoes sufficient stress when affected by diabetic conditions, chemotherapeutic drugs, and personal injury. Consequently, peripheral neuropathy arises as the most common complication, leading to debilitating symptoms that significantly alter the quality and way of life. The resulting chronic pain requires a treatment approach that does not simply mask the accompanying symptoms but provides the necessary external environment and neurotrophic factors that will effectively facilitate nerve regeneration. Under normal conditions, the peripheral nervous system self-regenerates very slowly. The rate of progression is further hindered by the development of fibrosis and scar tissue formation, which does not allow sufficient neurite outgrowth to the target site. By incorporating scaffolding supplemented with secretome derived from human mesenchymal stem cells, it is hypothesized that neurotrophic factors and cellular signaling can facilitate the optimal microenvironment for nerve reinnervation. However, conventional methods of secretory vesicle production are low yield, thus requiring improved methods to enhance paracrine secretions. This report highlights the state-of-the-art methods of neuropathy treatment as well as methods to optimize the clinical application of stem cells and derived secretory vesicles for nerve regeneration. |
| first_indexed | 2024-04-24T18:32:16Z |
| format | Article |
| id | doaj.art-5d25e8dfa97f4289bc6c5dfcc09e907c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-04-24T18:32:16Z |
| publishDate | 2024-02-01 |
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| spelling | doaj.art-5d25e8dfa97f4289bc6c5dfcc09e907c2024-03-27T13:22:30ZengMDPI AGBiomedicines2227-90592024-02-0112348910.3390/biomedicines12030489Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy ApplicationsDanyale Berry0Justice Ene1Aakash Nathani2Mandip Singh3Yan Li4Changchun Zeng5Department of Industrial and Manufacturing Engineering, FAMU-FSU College of Engineering, Florida Agricultural and Mechanical University, Tallahassee, FL 32310, USADepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL 32310, USACollege of Pharmacy and Pharmaceutical Sciences, Florida Agricultural and Mechanical University, Tallahassee, FL 32307, USACollege of Pharmacy and Pharmaceutical Sciences, Florida Agricultural and Mechanical University, Tallahassee, FL 32307, USADepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL 32310, USADepartment of Industrial and Manufacturing Engineering, FAMU-FSU College of Engineering, Florida Agricultural and Mechanical University, Tallahassee, FL 32310, USAThe peripheral nervous system undergoes sufficient stress when affected by diabetic conditions, chemotherapeutic drugs, and personal injury. Consequently, peripheral neuropathy arises as the most common complication, leading to debilitating symptoms that significantly alter the quality and way of life. The resulting chronic pain requires a treatment approach that does not simply mask the accompanying symptoms but provides the necessary external environment and neurotrophic factors that will effectively facilitate nerve regeneration. Under normal conditions, the peripheral nervous system self-regenerates very slowly. The rate of progression is further hindered by the development of fibrosis and scar tissue formation, which does not allow sufficient neurite outgrowth to the target site. By incorporating scaffolding supplemented with secretome derived from human mesenchymal stem cells, it is hypothesized that neurotrophic factors and cellular signaling can facilitate the optimal microenvironment for nerve reinnervation. However, conventional methods of secretory vesicle production are low yield, thus requiring improved methods to enhance paracrine secretions. This report highlights the state-of-the-art methods of neuropathy treatment as well as methods to optimize the clinical application of stem cells and derived secretory vesicles for nerve regeneration.https://www.mdpi.com/2227-9059/12/3/489peripheral neuropathystem cellsextracellular vesicleselectrical stimulationneurogenesis |
| spellingShingle | Danyale Berry Justice Ene Aakash Nathani Mandip Singh Yan Li Changchun Zeng Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications Biomedicines peripheral neuropathy stem cells extracellular vesicles electrical stimulation neurogenesis |
| title | Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications |
| title_full | Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications |
| title_fullStr | Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications |
| title_full_unstemmed | Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications |
| title_short | Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications |
| title_sort | effects of physical cues on stem cell derived extracellular vesicles toward neuropathy applications |
| topic | peripheral neuropathy stem cells extracellular vesicles electrical stimulation neurogenesis |
| url | https://www.mdpi.com/2227-9059/12/3/489 |
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