Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension
Background This study examined the associations between quantitative optical coherence tomography angiography (OCTA) parameters and myocardial abnormalities as documented on cardiovascular magnetic resonance imaging in patients with systemic hypertension. Methods and Results We conducted a cross‐sec...
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.024226 |
| _version_ | 1797859015810613248 |
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| author | Jacqueline Chua Thu‐Thao Le Yin Ci Sim Hui Yi Chye Bingyao Tan Xinwen Yao Damon Wong Briana W. Y. Ang Desiree‐Faye Toh Huishan Lim Jennifer A. Bryant Tien Yin Wong Calvin Woon Loong Chin Leopold Schmetterer |
| author_facet | Jacqueline Chua Thu‐Thao Le Yin Ci Sim Hui Yi Chye Bingyao Tan Xinwen Yao Damon Wong Briana W. Y. Ang Desiree‐Faye Toh Huishan Lim Jennifer A. Bryant Tien Yin Wong Calvin Woon Loong Chin Leopold Schmetterer |
| author_sort | Jacqueline Chua |
| collection | DOAJ |
| description | Background This study examined the associations between quantitative optical coherence tomography angiography (OCTA) parameters and myocardial abnormalities as documented on cardiovascular magnetic resonance imaging in patients with systemic hypertension. Methods and Results We conducted a cross‐sectional study of 118 adults with hypertension (197 eyes). Patients underwent cardiovascular magnetic resonance imaging and OCTA (PLEX Elite 9000, Carl Zeiss Meditec). Associations between OCTA parameters (superficial and deep retinal capillary density) and adverse cardiac remodeling (left ventricular mass, remodeling index, interstitial fibrosis, global longitudinal strain, and presence of left ventricular hypertrophy) were studied using multivariable linear regression analysis with generalized estimating equations. Of the 118 patients with hypertension enrolled (65% men; median [interquartile range] age, 59 [13] years), 29% had left ventricular hypertrophy. After adjusting for age, sex, systolic blood pressure, diabetes, and signal strength of OCTA scans, patients with lower superficial capillary density had significantly higher left ventricular mass (β=−0.150; 95% CI, −0.290 to −0.010), higher interstitial volume (β=−0.270; 95% CI, −0.535 to −0.0015), and worse global longitudinal strain (β=−0.109; 95% CI, −0.187 to −0.032). Lower superficial capillary density was found in patients with hypertension with replacement fibrosis versus no replacement fibrosis (16.53±0.64 mm‐1 versus 16.96±0.64 mm‐1; P=0.003). Conclusions We showed significant correlations between retinal capillary density and adverse cardiac remodeling markers in patients with hypertension, supporting the notion that the OCTA could provide a non‐invasive index of microcirculation alteration for vascular risk stratification in people with hypertension. |
| first_indexed | 2024-04-09T21:22:39Z |
| format | Article |
| id | doaj.art-5d27cf85cbbb4b75ab2b73c073f18080 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-09T21:22:39Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-5d27cf85cbbb4b75ab2b73c073f180802023-03-28T04:20:50ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-03-0111610.1161/JAHA.121.024226Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic HypertensionJacqueline Chua0Thu‐Thao Le1Yin Ci Sim2Hui Yi Chye3Bingyao Tan4Xinwen Yao5Damon Wong6Briana W. Y. Ang7Desiree‐Faye Toh8Huishan Lim9Jennifer A. Bryant10Tien Yin Wong11Calvin Woon Loong Chin12Leopold Schmetterer13Singapore Eye Research InstituteSingapore National Eye Centre Singapore SingaporeAcademic Clinical Program Duke‐NUS Medical School National University of Singapore Singapore SingaporeSingapore Eye Research InstituteSingapore National Eye Centre Singapore SingaporeSingapore Eye Research InstituteSingapore National Eye Centre Singapore SingaporeSingapore Eye Research InstituteSingapore National Eye Centre Singapore SingaporeSingapore Eye Research InstituteSingapore National Eye Centre Singapore SingaporeSingapore Eye Research InstituteSingapore National Eye Centre Singapore SingaporeNational Heart Research Institute SingaporeNational Heart Centre Singapore Singapore SingaporeNational Heart Research Institute SingaporeNational Heart Centre Singapore Singapore SingaporeNational Heart Research Institute SingaporeNational Heart Centre Singapore Singapore SingaporeNational Heart Research Institute SingaporeNational Heart Centre Singapore Singapore SingaporeSingapore Eye Research InstituteSingapore National Eye Centre Singapore SingaporeAcademic Clinical Program Duke‐NUS Medical School National University of Singapore Singapore SingaporeSingapore Eye Research InstituteSingapore National Eye Centre Singapore SingaporeBackground This study examined the associations between quantitative optical coherence tomography angiography (OCTA) parameters and myocardial abnormalities as documented on cardiovascular magnetic resonance imaging in patients with systemic hypertension. Methods and Results We conducted a cross‐sectional study of 118 adults with hypertension (197 eyes). Patients underwent cardiovascular magnetic resonance imaging and OCTA (PLEX Elite 9000, Carl Zeiss Meditec). Associations between OCTA parameters (superficial and deep retinal capillary density) and adverse cardiac remodeling (left ventricular mass, remodeling index, interstitial fibrosis, global longitudinal strain, and presence of left ventricular hypertrophy) were studied using multivariable linear regression analysis with generalized estimating equations. Of the 118 patients with hypertension enrolled (65% men; median [interquartile range] age, 59 [13] years), 29% had left ventricular hypertrophy. After adjusting for age, sex, systolic blood pressure, diabetes, and signal strength of OCTA scans, patients with lower superficial capillary density had significantly higher left ventricular mass (β=−0.150; 95% CI, −0.290 to −0.010), higher interstitial volume (β=−0.270; 95% CI, −0.535 to −0.0015), and worse global longitudinal strain (β=−0.109; 95% CI, −0.187 to −0.032). Lower superficial capillary density was found in patients with hypertension with replacement fibrosis versus no replacement fibrosis (16.53±0.64 mm‐1 versus 16.96±0.64 mm‐1; P=0.003). Conclusions We showed significant correlations between retinal capillary density and adverse cardiac remodeling markers in patients with hypertension, supporting the notion that the OCTA could provide a non‐invasive index of microcirculation alteration for vascular risk stratification in people with hypertension.https://www.ahajournals.org/doi/10.1161/JAHA.121.024226cardiovascular magnetic resonanceoptical coherence tomography angiographysystemic hypertension |
| spellingShingle | Jacqueline Chua Thu‐Thao Le Yin Ci Sim Hui Yi Chye Bingyao Tan Xinwen Yao Damon Wong Briana W. Y. Ang Desiree‐Faye Toh Huishan Lim Jennifer A. Bryant Tien Yin Wong Calvin Woon Loong Chin Leopold Schmetterer Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular magnetic resonance optical coherence tomography angiography systemic hypertension |
| title | Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension |
| title_full | Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension |
| title_fullStr | Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension |
| title_full_unstemmed | Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension |
| title_short | Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension |
| title_sort | relationship of quantitative retinal capillary network and myocardial remodeling in systemic hypertension |
| topic | cardiovascular magnetic resonance optical coherence tomography angiography systemic hypertension |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.024226 |
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