Two methoxy derivatives of resveratrol, 3,3′,4,5′-tetramethoxy-trans-stilbene and 3,4′,5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells

Two methoxy derivatives of resveratrol, 3,3′,4,5′-tetramethoxy-trans-stilbene and 3,4′,5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells

Abstract Background 3,3′,4,5′-tetramethoxy-trans-stilbene (3,3′,4,5′-TMS) and 3,4′,5-trimethoxy-trans-stilbene (3,4′,5-TMS) are two methoxy derivatives of resveratrol. Previous researches have proved that resveratrol and its analogues have anti-inflammatory effect through suppressing mitogen-activat...

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Bibliographic Details
Main Authors: Chunxiu Zhou, Xutao Zhang, Cheng-Chao Ruan, Wai San Cheang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Chinese Medicine
Subjects:
3,3′,4,5′-tetramethoxy-trans-stilbene
3,4′,5-trimethoxy-trans-stilbene
Inflammation
Lipopolysaccharide
MAPK
NF-κB
Online Access:https://doi.org/10.1186/s13020-021-00480-9

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