Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women
Chronic kidney disease (CKD) is a global health threat of growing concern. Recently, exposure to endocrine disrupting compounds (EDCs) such as phthalates and bisphenol A has been suggested as a risk factor for CKD. However, most epidemiological studies have focused on a limited number of urinary che...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-03-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018330599 |
| _version_ | 1818969676552601600 |
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| author | Habyeong Kang Sunmi Kim Gowoon Lee Inae Lee Jung Pyo Lee Jeonghwan Lee Hyunwoong Park Hyo-Bang Moon Jeongim Park Sungkyoon Kim Gyuyeon Choi Kyungho Choi |
| author_facet | Habyeong Kang Sunmi Kim Gowoon Lee Inae Lee Jung Pyo Lee Jeonghwan Lee Hyunwoong Park Hyo-Bang Moon Jeongim Park Sungkyoon Kim Gyuyeon Choi Kyungho Choi |
| author_sort | Habyeong Kang |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a global health threat of growing concern. Recently, exposure to endocrine disrupting compounds (EDCs) such as phthalates and bisphenol A has been suggested as a risk factor for CKD. However, most epidemiological studies have focused on a limited number of urinary chemicals. This study aimed to identify chemical determinants of the urinary albumin-to-creatinine ratio (ACR), which is a kidney function marker, among multiple major EDCs including phthalate metabolites, bisphenols, and benzophenones in a Korean female population (20–45 years old, n = 441). First, the creatinine-adjusted urinary concentration of each urinary chemical was associated with ACR in a linear regression model (single-pollutant model). Then, compounds with a significant association with ACR in the single-pollutant model were added in a multi-pollutant model and evaluated for their association with ACR. Moreover, to prevent potential reverse causality due to impaired kidney function, quartile analyses were performed for the subjects with healthy renal function (ACR < 9.71 mg/g). In addition to creatinine adjustment, the statistical analysis was also conducted with specific gravity-adjusted concentrations of urinary chemicals, and the results were compared. Several compounds measured in the urine showed a significant association with ACR in the single-pollutant model. In the multi-pollutant model, however, only monobutyl phthalate and benzophenone-1, which are metabolites of dibutyl phthalate and benzophenone-3, respectively, showed significant positive associations. The association of these chemicals remained significant in a couple of the sensitivity analyses with a different adjustment of urine dilution and in a subpopulation with normal ACR. In conclusion, among dozens of urinary chemicals, monobutyl phthalate and benzophenone-1 consistently showed a strong association with urinary ACR. Confirmation of our observation in other human populations and experimental studies is warranted. Keywords: Endocrine disrupting chemicals (EDCs), Chronic kidney disease (CKD), Albumin-to-creatinine ratio (ACR), Low molecular weight phthalates, Benzophenones, Environmental phenols |
| first_indexed | 2024-12-20T14:24:22Z |
| format | Article |
| id | doaj.art-5d345ffe93974cd5bdfca5f9d0c3c2b1 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-20T14:24:22Z |
| publishDate | 2019-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-5d345ffe93974cd5bdfca5f9d0c3c2b12022-12-21T19:37:50ZengElsevierEnvironment International0160-41202019-03-01124354360Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy womenHabyeong Kang0Sunmi Kim1Gowoon Lee2Inae Lee3Jung Pyo Lee4Jeonghwan Lee5Hyunwoong Park6Hyo-Bang Moon7Jeongim Park8Sungkyoon Kim9Gyuyeon Choi10Kyungho Choi11Department of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul, Republic of KoreaDepartment of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul, Republic of KoreaDepartment of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul, Republic of KoreaDepartment of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of KoreaDepartment of Laboratory Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of KoreaDepartment of Marine Science and Convergence Engineering, Hanyang University, Ansan, Republic of KoreaDepartment of Natural Sciences, Soonchunhyang University, Asan, Republic of KoreaDepartment of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Seoul, Republic of KoreaDepartment of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul, Republic of Korea; Corresponding author at: School of Public Health, Seoul National University, Gwanak, Seoul 08826, Republic of Korea.Chronic kidney disease (CKD) is a global health threat of growing concern. Recently, exposure to endocrine disrupting compounds (EDCs) such as phthalates and bisphenol A has been suggested as a risk factor for CKD. However, most epidemiological studies have focused on a limited number of urinary chemicals. This study aimed to identify chemical determinants of the urinary albumin-to-creatinine ratio (ACR), which is a kidney function marker, among multiple major EDCs including phthalate metabolites, bisphenols, and benzophenones in a Korean female population (20–45 years old, n = 441). First, the creatinine-adjusted urinary concentration of each urinary chemical was associated with ACR in a linear regression model (single-pollutant model). Then, compounds with a significant association with ACR in the single-pollutant model were added in a multi-pollutant model and evaluated for their association with ACR. Moreover, to prevent potential reverse causality due to impaired kidney function, quartile analyses were performed for the subjects with healthy renal function (ACR < 9.71 mg/g). In addition to creatinine adjustment, the statistical analysis was also conducted with specific gravity-adjusted concentrations of urinary chemicals, and the results were compared. Several compounds measured in the urine showed a significant association with ACR in the single-pollutant model. In the multi-pollutant model, however, only monobutyl phthalate and benzophenone-1, which are metabolites of dibutyl phthalate and benzophenone-3, respectively, showed significant positive associations. The association of these chemicals remained significant in a couple of the sensitivity analyses with a different adjustment of urine dilution and in a subpopulation with normal ACR. In conclusion, among dozens of urinary chemicals, monobutyl phthalate and benzophenone-1 consistently showed a strong association with urinary ACR. Confirmation of our observation in other human populations and experimental studies is warranted. Keywords: Endocrine disrupting chemicals (EDCs), Chronic kidney disease (CKD), Albumin-to-creatinine ratio (ACR), Low molecular weight phthalates, Benzophenones, Environmental phenolshttp://www.sciencedirect.com/science/article/pii/S0160412018330599 |
| spellingShingle | Habyeong Kang Sunmi Kim Gowoon Lee Inae Lee Jung Pyo Lee Jeonghwan Lee Hyunwoong Park Hyo-Bang Moon Jeongim Park Sungkyoon Kim Gyuyeon Choi Kyungho Choi Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women Environment International |
| title | Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women |
| title_full | Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women |
| title_fullStr | Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women |
| title_full_unstemmed | Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women |
| title_short | Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women |
| title_sort | urinary metabolites of dibutyl phthalate and benzophenone 3 are potential chemical risk factors of chronic kidney function markers among healthy women |
| url | http://www.sciencedirect.com/science/article/pii/S0160412018330599 |
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