Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion
Botanicals with remarkable pharmacological properties include Zingiber officinale Roscoe [Zingiberaceae] (ginger) and Gymnanthemum amygdalinum (Delie) Sch. Bip [Asteraceae] (bitterleaf). The plants are frequently used as teas and decoctions, and have been studied in the treatment of various illnesse...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222011775 |
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| author | Tobiloba Christiana Elebiyo Oghenemaero Oghale Olori Damilare Emmanuel Rotimi Wafa Abdullah I. Al-Megrin Michel De Waard Afrah Fahd Alkhuriji Gaber El-Saber Batiha Adebukola Anne Adeyanju Oluyomi Stephen Adeyemi |
| author_facet | Tobiloba Christiana Elebiyo Oghenemaero Oghale Olori Damilare Emmanuel Rotimi Wafa Abdullah I. Al-Megrin Michel De Waard Afrah Fahd Alkhuriji Gaber El-Saber Batiha Adebukola Anne Adeyanju Oluyomi Stephen Adeyemi |
| author_sort | Tobiloba Christiana Elebiyo |
| collection | DOAJ |
| description | Botanicals with remarkable pharmacological properties include Zingiber officinale Roscoe [Zingiberaceae] (ginger) and Gymnanthemum amygdalinum (Delie) Sch. Bip [Asteraceae] (bitterleaf). The plants are frequently used as teas and decoctions, and have been studied in the treatment of various illnesses. Thus, this study investigated the in vitro antioxidant activities and chemical fingerprints of ginger and bitter leaf infusions separately and as a combination. In addition, we assessed the effects of the tea infusions on rat liver and kidney indices. The findings from this study showed that the bitterleaf infusion had the highest phenolic content (21.77 ± 3.140 µg gallic acid equivalent/mg) in comparison with that of ginger (15.17 ± 1.50 µg gallic acid equivalent/mg) and their combination (8.81 ± 0.48 µg gallic acid equivalent/mg). The ginger infusion had the highest flavonoid content (547.15 ± 1.17 µg quercetin equivalent/mg), which was preceded by bitterleaf (473.02 ± 10.48 µg quercetin equivalent/mg) and the ginger and bitterleaf infusion (415.08 ± 4.15 µg quercetin equivalent/mg). Furthermore, our results showed that the tea infusions had no significant effect on the liver function indices (ALT and AST) compared to the control. In contrast, the rat plasma urea significantly increased in the groups given bitterleaf and a combination of ginger and bitterleaf infusions, while creatinine significantly decreased in the group that received the combined form of the infusion. The GC-MS analysis of ginger and bitterleaf infusions revealed that n-hexadecanoic acid, oleic acid, and ergosterol were most abundant in the bitterleaf infusion. At the same time, gingerol, 2-butanone, and 4-(4-hydroxy-3-methoxyphenyl) were the most abundant in the ginger infusion. Together, the findings are not only evidence in support of the medicinal value of these plants but also reinforce their prospects as nutriceuticals. |
| first_indexed | 2024-04-11T08:39:46Z |
| format | Article |
| id | doaj.art-5d352d920821468b9ac429e264d6ca7c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T08:39:46Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-5d352d920821468b9ac429e264d6ca7c2022-12-22T04:34:14ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-11-01155113788Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusionTobiloba Christiana Elebiyo0Oghenemaero Oghale Olori1Damilare Emmanuel Rotimi2Wafa Abdullah I. Al-Megrin3Michel De Waard4Afrah Fahd Alkhuriji5Gaber El-Saber Batiha6Adebukola Anne Adeyanju7Oluyomi Stephen Adeyemi8SDG 03 Group – Good Health & Well-being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria; Department of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran 251101, NigeriaSDG 03 Group – Good Health & Well-being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria; Department of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran 251101, NigeriaSDG 03 Group – Good Health & Well-being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria; Department of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran 251101, NigeriaDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaNantes Université, CNRS, INSERM, l′Institut du thorax, F-44000 Nantes, France; LabEx Ion Channels, Science and Therapeutics, Valbonne, France; Martox Biotechnology, 6 rue des Platanes, 38120 Saint-Egrève, FranceDepartment of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, EgyptDepartment of Biological Sciences, Faculty of Applied Sciences, KolaDaisi University, Ibadan, NigeriaSDG 03 Group – Good Health & Well-being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria; Department of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran 251101, Nigeria; Laboratory of Sustainable Animal Environment, Graduate School of Agricultural Science, Tohoku University, 232-3 Yomogida, Naruko-onsen, Osaki, Miyagi 989-6711, Japan; Corresponding author at: Department of Biochemistry, Landmark University, Omu-Aran 251101, Kwara State, Nigeria.Botanicals with remarkable pharmacological properties include Zingiber officinale Roscoe [Zingiberaceae] (ginger) and Gymnanthemum amygdalinum (Delie) Sch. Bip [Asteraceae] (bitterleaf). The plants are frequently used as teas and decoctions, and have been studied in the treatment of various illnesses. Thus, this study investigated the in vitro antioxidant activities and chemical fingerprints of ginger and bitter leaf infusions separately and as a combination. In addition, we assessed the effects of the tea infusions on rat liver and kidney indices. The findings from this study showed that the bitterleaf infusion had the highest phenolic content (21.77 ± 3.140 µg gallic acid equivalent/mg) in comparison with that of ginger (15.17 ± 1.50 µg gallic acid equivalent/mg) and their combination (8.81 ± 0.48 µg gallic acid equivalent/mg). The ginger infusion had the highest flavonoid content (547.15 ± 1.17 µg quercetin equivalent/mg), which was preceded by bitterleaf (473.02 ± 10.48 µg quercetin equivalent/mg) and the ginger and bitterleaf infusion (415.08 ± 4.15 µg quercetin equivalent/mg). Furthermore, our results showed that the tea infusions had no significant effect on the liver function indices (ALT and AST) compared to the control. In contrast, the rat plasma urea significantly increased in the groups given bitterleaf and a combination of ginger and bitterleaf infusions, while creatinine significantly decreased in the group that received the combined form of the infusion. The GC-MS analysis of ginger and bitterleaf infusions revealed that n-hexadecanoic acid, oleic acid, and ergosterol were most abundant in the bitterleaf infusion. At the same time, gingerol, 2-butanone, and 4-(4-hydroxy-3-methoxyphenyl) were the most abundant in the ginger infusion. Together, the findings are not only evidence in support of the medicinal value of these plants but also reinforce their prospects as nutriceuticals.http://www.sciencedirect.com/science/article/pii/S0753332222011775Botanical drugsGymnanthemum amygdalinum (delie)Medicinal biochemistryPhytochemical analysisZingiber officinale RoscoeTea infusion |
| spellingShingle | Tobiloba Christiana Elebiyo Oghenemaero Oghale Olori Damilare Emmanuel Rotimi Wafa Abdullah I. Al-Megrin Michel De Waard Afrah Fahd Alkhuriji Gaber El-Saber Batiha Adebukola Anne Adeyanju Oluyomi Stephen Adeyemi Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion Biomedicine & Pharmacotherapy Botanical drugs Gymnanthemum amygdalinum (delie) Medicinal biochemistry Phytochemical analysis Zingiber officinale Roscoe Tea infusion |
| title | Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion |
| title_full | Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion |
| title_fullStr | Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion |
| title_full_unstemmed | Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion |
| title_short | Chemical fingerprinting, comparative in vitro antioxidant properties, and biochemical effects of ginger and bitterleaf infusion |
| title_sort | chemical fingerprinting comparative in vitro antioxidant properties and biochemical effects of ginger and bitterleaf infusion |
| topic | Botanical drugs Gymnanthemum amygdalinum (delie) Medicinal biochemistry Phytochemical analysis Zingiber officinale Roscoe Tea infusion |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222011775 |
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