Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19

Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19

Abstract Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. W...

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Bibliographic Details
Main Authors: Meng Yu, Afandi Charles, Alberto Cagigi, Wanda Christ, Björn Österberg, Sara Falck-Jones, Lida Azizmohammadi, Eric Åhlberg, Ryan Falck-Jones, Julia Svensson, Mu Nie, Anna Warnqvist, Fredrika Hellgren, Klara Lenart, Rodrigo Arcoverde Cerveira, Sebastian Ols, Gustaf Lindgren, Ang Lin, Holden Maecker, Max Bell, Niclas Johansson, Jan Albert, Christopher Sundling, Paulo Czarnewski, Jonas Klingström, Anna Färnert, Karin Loré, Anna Smed-Sörensen
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37835-9

Internet

https://doi.org/10.1038/s41467-023-37835-9

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