Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile Males
Accurate diagnosis of the cause of infertility assists in the choice of treatment modalities and amelioration of the associated psychosocial problems. The research was carried out using 75 infertile males and 75 males with proven fertility as controls. The anthropometrics (weight, height) were meas...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-07-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/9261 |
| _version_ | 1797768481836367872 |
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| author | Wasiu Eniola Olooto Hammed A Adenusi Joseph O Soola Monisola A Ayodele Frank E Agidigbi |
| author_facet | Wasiu Eniola Olooto Hammed A Adenusi Joseph O Soola Monisola A Ayodele Frank E Agidigbi |
| author_sort | Wasiu Eniola Olooto |
| collection | DOAJ |
| description |
Accurate diagnosis of the cause of infertility assists in the choice of treatment modalities and amelioration of the associated psychosocial problems. The research was carried out using 75 infertile males and 75 males with proven fertility as controls. The anthropometrics (weight, height) were measured and body mass index (BMI) computed. Venous blood was collected from each participant, allowed to clot, and centrifuged to obtain the serum which was analysed for testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations. Semen was collected by masturbation and analysed for sperm quality, seminal fructose concentration, and histone deacetylase (HDAC) activities. A non-significant difference (P>0.05) in weight, height, and BMI; a significant increase (P<0.05) in ejaculated volume, serum LH, FSH, seminal fructose concentrations and HDAC activities; and a decrease in sperm count, sperm motility, serum testosterone concentration was observed among subgroups of infertile men. A direct and significant correlation exists between seminal HDAC activities and fructose concentration. Also, an inverse non-significant correlation exists between HDAC activities and spermatozoa motility. Base on the result obtained from this study, it can be concluded that measuring seminal fructose and HDAC activities in addition to routine biochemical and biophysical parameters will assist in diagnostic work up in subgroups of male infertility.
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| first_indexed | 2024-03-12T20:54:19Z |
| format | Article |
| id | doaj.art-5d3af36fcf144680b6ae5e46decd1d1c |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-03-12T20:54:19Z |
| publishDate | 2023-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-5d3af36fcf144680b6ae5e46decd1d1c2023-07-31T20:43:54ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942023-07-0161410.18502/acta.v61i4.13170Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile MalesWasiu Eniola Olooto0Hammed A Adenusi1Joseph O Soola2Monisola A Ayodele3Frank E Agidigbi4Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Ago-Iwoye, Ogun, NigeriaDepartment of Chemical Pathology and Immunology, Olabisi Onabanjo University, Ago-Iwoye, Ogun, NigeriaDepartment of Physiology, Olabisi Onabanjo University, Ago-Iwoye, Ogun, NigeriaDepartment of Chemical Pathology and Immunology, Olabisi Onabanjo University, Ago-Iwoye, Ogun, NigeriaSchool of Medical Laboratory Technology, Baptist Medical Center, Saki, Nigeria Accurate diagnosis of the cause of infertility assists in the choice of treatment modalities and amelioration of the associated psychosocial problems. The research was carried out using 75 infertile males and 75 males with proven fertility as controls. The anthropometrics (weight, height) were measured and body mass index (BMI) computed. Venous blood was collected from each participant, allowed to clot, and centrifuged to obtain the serum which was analysed for testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations. Semen was collected by masturbation and analysed for sperm quality, seminal fructose concentration, and histone deacetylase (HDAC) activities. A non-significant difference (P>0.05) in weight, height, and BMI; a significant increase (P<0.05) in ejaculated volume, serum LH, FSH, seminal fructose concentrations and HDAC activities; and a decrease in sperm count, sperm motility, serum testosterone concentration was observed among subgroups of infertile men. A direct and significant correlation exists between seminal HDAC activities and fructose concentration. Also, an inverse non-significant correlation exists between HDAC activities and spermatozoa motility. Base on the result obtained from this study, it can be concluded that measuring seminal fructose and HDAC activities in addition to routine biochemical and biophysical parameters will assist in diagnostic work up in subgroups of male infertility. https://acta.tums.ac.ir/index.php/acta/article/view/9261Seminal fructosehistone deacetylasesinfertile menadipositygonadotropins |
| spellingShingle | Wasiu Eniola Olooto Hammed A Adenusi Joseph O Soola Monisola A Ayodele Frank E Agidigbi Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile Males Acta Medica Iranica Seminal fructose histone deacetylases infertile men adiposity gonadotropins |
| title | Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile Males |
| title_full | Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile Males |
| title_fullStr | Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile Males |
| title_full_unstemmed | Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile Males |
| title_short | Seminal Histone Deacetylase, Fructose and Serum Reproductive Hormones as Diagnostic Marker in Sub-Groups of Infertile Males |
| title_sort | seminal histone deacetylase fructose and serum reproductive hormones as diagnostic marker in sub groups of infertile males |
| topic | Seminal fructose histone deacetylases infertile men adiposity gonadotropins |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/9261 |
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