计算机化甲襞视频毛细血管镜在2型糖尿病中的运用: 对102例门诊患者的横断面研究
Abstract Background Type 2 diabetes (T2D) is a chronic disease that negatively affects vascular health. A careful assessment of chronic complications, including microcirculation, is mandatory. The computerized nailfold video‐capillaroscopy (CNVC) accurately examines the nailfold microvasculature, bu...
| Glavni autori: | , |
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| Format: | Članak |
| Jezik: | English |
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Wiley
2023-10-01
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| Serija: | Journal of Diabetes |
| Teme: | |
| Online pristup: | https://doi.org/10.1111/1753-0407.13442 |
| _version_ | 1827787134543593472 |
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| author | Giuseppe Lisco Vincenzo Triggiani |
| author_facet | Giuseppe Lisco Vincenzo Triggiani |
| author_sort | Giuseppe Lisco |
| collection | DOAJ |
| description | Abstract Background Type 2 diabetes (T2D) is a chronic disease that negatively affects vascular health. A careful assessment of chronic complications, including microcirculation, is mandatory. The computerized nailfold video‐capillaroscopy (CNVC) accurately examines the nailfold microvasculature, but its suitability in T2D is currently under investigation. Aims To describe nailfold microvasculature in T2D patients regarding the level of glucose control and chronic microvascular and macrovascular complications. Methods This is a cross‐sectional study on 102 consecutive and unselected outpatients with T2D who had undergone CNVC examination. The examination was carried out by using an electronic video‐capillaroscope with 300x magnification. Capillaroscopic appearance and capillary changes were described according to well‐established parameters. Capillaroscopic parameters were compared between patients with poor glucose control (HbA1c ≥7%) and those with better glucose control (HbA1c <7%) and between patients with chronic complications and those without. Chronic complications were deduced from the anamnestic, laboratory, and instrumental data and the five‐item International Index of Erectile Function (IIEF‐5) questionnaire. Results Nailfold capillaries in patients with HbA1c ≥7% were thicker (p = .019) and longer (p = .021) than in those with better glucose control. Ectasias (p = .017) and microaneurysms (p = .045) were more frequently observed in patients with HbA1c ≥7.0% than those with HbA1c <7.0%. Patients with ED, compared to those without, had a lower frequency of bizarre‐shaped capillaries (p = .02). Microaneurysms (p = .02) were more frequently described in patients with carotid stenosis (>20%) than those without. Conclusion Relevant nailfold microvascular alterations were observed in T2D, most of which were associated with poor glycemic control, ED, and carotid stenosis. Further investigation is needed to recognize the role of CNVC in predicting the onset and evolution of chronic complications and monitoring the effectiveness of antihyperglycemic treatments on microcirculation. |
| first_indexed | 2024-03-11T16:45:14Z |
| format | Article |
| id | doaj.art-5d3b7b3bc03d4c72843e225d09e8ddbc |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-03-11T16:45:14Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-5d3b7b3bc03d4c72843e225d09e8ddbc2023-10-22T23:46:44ZengWileyJournal of Diabetes1753-03931753-04072023-10-01151089089910.1111/1753-0407.13442计算机化甲襞视频毛细血管镜在2型糖尿病中的运用: 对102例门诊患者的横断面研究Giuseppe Lisco0Vincenzo Triggiani1Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine University of Bari Aldo Moro Bari ItalyInterdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine University of Bari Aldo Moro Bari ItalyAbstract Background Type 2 diabetes (T2D) is a chronic disease that negatively affects vascular health. A careful assessment of chronic complications, including microcirculation, is mandatory. The computerized nailfold video‐capillaroscopy (CNVC) accurately examines the nailfold microvasculature, but its suitability in T2D is currently under investigation. Aims To describe nailfold microvasculature in T2D patients regarding the level of glucose control and chronic microvascular and macrovascular complications. Methods This is a cross‐sectional study on 102 consecutive and unselected outpatients with T2D who had undergone CNVC examination. The examination was carried out by using an electronic video‐capillaroscope with 300x magnification. Capillaroscopic appearance and capillary changes were described according to well‐established parameters. Capillaroscopic parameters were compared between patients with poor glucose control (HbA1c ≥7%) and those with better glucose control (HbA1c <7%) and between patients with chronic complications and those without. Chronic complications were deduced from the anamnestic, laboratory, and instrumental data and the five‐item International Index of Erectile Function (IIEF‐5) questionnaire. Results Nailfold capillaries in patients with HbA1c ≥7% were thicker (p = .019) and longer (p = .021) than in those with better glucose control. Ectasias (p = .017) and microaneurysms (p = .045) were more frequently observed in patients with HbA1c ≥7.0% than those with HbA1c <7.0%. Patients with ED, compared to those without, had a lower frequency of bizarre‐shaped capillaries (p = .02). Microaneurysms (p = .02) were more frequently described in patients with carotid stenosis (>20%) than those without. Conclusion Relevant nailfold microvascular alterations were observed in T2D, most of which were associated with poor glycemic control, ED, and carotid stenosis. Further investigation is needed to recognize the role of CNVC in predicting the onset and evolution of chronic complications and monitoring the effectiveness of antihyperglycemic treatments on microcirculation.https://doi.org/10.1111/1753-0407.13442计算机化甲襞视频毛细血管镜2型糖尿病勃起功能障碍糖尿病视网膜病变慢性肾病心血管疾病 |
| spellingShingle | Giuseppe Lisco Vincenzo Triggiani 计算机化甲襞视频毛细血管镜在2型糖尿病中的运用: 对102例门诊患者的横断面研究 Journal of Diabetes 计算机化甲襞视频毛细血管镜 2型糖尿病 勃起功能障碍 糖尿病视网膜病变 慢性肾病 心血管疾病 |
| title | 计算机化甲襞视频毛细血管镜在2型糖尿病中的运用: 对102例门诊患者的横断面研究 |
| title_full | 计算机化甲襞视频毛细血管镜在2型糖尿病中的运用: 对102例门诊患者的横断面研究 |
| title_fullStr | 计算机化甲襞视频毛细血管镜在2型糖尿病中的运用: 对102例门诊患者的横断面研究 |
| title_full_unstemmed | 计算机化甲襞视频毛细血管镜在2型糖尿病中的运用: 对102例门诊患者的横断面研究 |
| title_short | 计算机化甲襞视频毛细血管镜在2型糖尿病中的运用: 对102例门诊患者的横断面研究 |
| title_sort | 计算机化甲襞视频毛细血管镜在2型糖尿病中的运用 对102例门诊患者的横断面研究 |
| topic | 计算机化甲襞视频毛细血管镜 2型糖尿病 勃起功能障碍 糖尿病视网膜病变 慢性肾病 心血管疾病 |
| url | https://doi.org/10.1111/1753-0407.13442 |
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