Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report
Sjögren’s syndrome is an autoimmune disease that can affect multiple systems. Sjögren’s syndrome with motor neuron disease is rarely reported. Herein, we describe a patient with rapidly progressive motor neuron disease secondary to Sjögren’s syndrome. A 42-year-old woman was admitted to our hospital...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520974465 |
| _version_ | 1819292653437583360 |
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| author | Huijia Yang Xiaozhong Jing Jinhua Yan Dihui Ma |
| author_facet | Huijia Yang Xiaozhong Jing Jinhua Yan Dihui Ma |
| author_sort | Huijia Yang |
| collection | DOAJ |
| description | Sjögren’s syndrome is an autoimmune disease that can affect multiple systems. Sjögren’s syndrome with motor neuron disease is rarely reported. Herein, we describe a patient with rapidly progressive motor neuron disease secondary to Sjögren’s syndrome. A 42-year-old woman was admitted to our hospital with a 2-month history of progressive limb weakness. Neurological assessment revealed fasciculation in the lower limbs and amyotrophy in the bilateral supraspinatus, interosseous, and thenar muscles. Serological examination and labial gland biopsy revealed Sjögren’s syndrome. In addition, electromyography demonstrated neurogenic damage to the upper and lower limbs. The patient received a short course of high-dose corticosteroids, intravenous immunoglobulins, and immunosuppressant treatment, including a weekly dose of 0.4 g cyclophosphamide and a daily dose of 0.2 g hydroxychloroquine. However, the patient’s limb weakness was further aggravated and her respiratory function was compromised. Electromyography re-examination demonstrated extensive neurogenic damage, and she was diagnosed with Sjögren’s syndrome with motor neuron disease. The patient died of respiratory failure after 2 months. We suggest that more effective maintenance treatments should be sought. Further investigation is required to elucidate the association between autoimmune motor neuron disease and Sjögren’s syndrome. |
| first_indexed | 2024-12-24T03:57:57Z |
| format | Article |
| id | doaj.art-5d3b8b6562da42828b11af0d1b541f1e |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-24T03:57:57Z |
| publishDate | 2020-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-5d3b8b6562da42828b11af0d1b541f1e2022-12-21T17:16:23ZengSAGE PublishingJournal of International Medical Research1473-23002020-11-014810.1177/0300060520974465Sjögren’s syndrome with rapidly progressive motor neuron disease: a case reportHuijia YangXiaozhong JingJinhua YanDihui MaSjögren’s syndrome is an autoimmune disease that can affect multiple systems. Sjögren’s syndrome with motor neuron disease is rarely reported. Herein, we describe a patient with rapidly progressive motor neuron disease secondary to Sjögren’s syndrome. A 42-year-old woman was admitted to our hospital with a 2-month history of progressive limb weakness. Neurological assessment revealed fasciculation in the lower limbs and amyotrophy in the bilateral supraspinatus, interosseous, and thenar muscles. Serological examination and labial gland biopsy revealed Sjögren’s syndrome. In addition, electromyography demonstrated neurogenic damage to the upper and lower limbs. The patient received a short course of high-dose corticosteroids, intravenous immunoglobulins, and immunosuppressant treatment, including a weekly dose of 0.4 g cyclophosphamide and a daily dose of 0.2 g hydroxychloroquine. However, the patient’s limb weakness was further aggravated and her respiratory function was compromised. Electromyography re-examination demonstrated extensive neurogenic damage, and she was diagnosed with Sjögren’s syndrome with motor neuron disease. The patient died of respiratory failure after 2 months. We suggest that more effective maintenance treatments should be sought. Further investigation is required to elucidate the association between autoimmune motor neuron disease and Sjögren’s syndrome.https://doi.org/10.1177/0300060520974465 |
| spellingShingle | Huijia Yang Xiaozhong Jing Jinhua Yan Dihui Ma Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report Journal of International Medical Research |
| title | Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report |
| title_full | Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report |
| title_fullStr | Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report |
| title_full_unstemmed | Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report |
| title_short | Sjögren’s syndrome with rapidly progressive motor neuron disease: a case report |
| title_sort | sjogren s syndrome with rapidly progressive motor neuron disease a case report |
| url | https://doi.org/10.1177/0300060520974465 |
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