Deleterious Rare Mutations of GLI1 Dysregulate Sonic Hedgehog Signaling in Human Congenital Heart Disease

Deleterious Rare Mutations of GLI1 Dysregulate Sonic Hedgehog Signaling in Human Congenital Heart Disease

The Glioma-associated oncogene (Gli) family members of zinc finger DNA-binding proteins are core effectors of Sonic hedgehog (SHH) signaling pathway. Studies in model organisms have identified that the Gli genes play critical roles during organ development, including the heart, brain, kidneys, etc....

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Bibliographic Details
Main Authors: Rui Peng, Binbin Li, Shuxia Chen, Zhiwen Shi, Liwei Yu, Yunqian Gao, Xueyan Yang, Lei Lu, Hongyan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
congenital heart disease (CHD)
GLI1
genetic variant
rare mutation
Sonic hedgehog (SHH) signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.798033/full

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